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Abstract: SA-PO395

Dental Caries and Cardiometabolic Health in Adolescents

Session Information

  • Pediatric Nephrology - III
    November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

  • 1900 Pediatric Nephrology

Authors

  • Wong, Kristal, Cohen Children's Medical Center, Queens, New York, United States
  • Nadella, Srighana, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, United States
  • Mupparapu, Mel, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, United States
  • Sethna, Christine B., Cohen Children's Medical Center, Queens, New York, United States
Background

Dental caries is the most common chronic disease in the pediatric population. Prior studies suggest that poor oral health may contribute to an increased risk of metabolic syndrome and cardiovascular risk in adulthood. The aim was to assess the association between dental caries and cardiometabolic risk in adolescents.

Methods

Analysis included adolescents aged 13-17 years enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2011-2018 who completed an oral health questionnaire/exam. Untreated caries was defined as having one or more decayed teeth. Severity of dental caries was assessed by the Decayed, Missing, Filled Teeth (DMFT) score in permanent dentition (No caries, DMFT=0). Cardiometabolic outcomes included obesity, elevated BP (BP 120-129/<80 mmHg), hypertensive BP (BP >130/80 mmHg), dyslipidemia (any abnormal lipid level), glucose intolerance (HOMA-IR), uric acid, glomerular hyperfiltration (estimated glomerular filtration rate [eGFR] >140 ml/min/1.72 m2), and microalbuminuria (urine albumin:creatinine >30 mg/mg). Regression models adjusted for age, sex, self-identified ethnicity/race, household income, food insecurity, health insurance status, household education, and body mass index (BMI) z-score examined associations using complex survey design procedures.

Results

Of 2,861 adolescents (age 14.97 [0.03] years, 55.3% [1.2%] male), 25.6% (1.3%) had untreated caries and 55.4% [1.3%] had DMFT >1. In adjusted models, untreated caries was significantly associated with higher HOMA-IR levels and lower eGFR values. Additionally, DMFT >1 was associated with higher odds of elevated BP compared to a DMFT of 0 (Table 1).

Conclusion

In a nationally representative study of adolescents, there was an association between untreated/more severe caries with cardiometabolic markers of BP and glucose intolerance.

Funding

  • NIDDK Support