Abstract: TH-PO1082
Association Between Declining Kidney Function and Abdominal Aortic Calcification: Insights from NHANES Study
Session Information
- CKD Progression and Complications: Diagnosis, Prognosis, Risk Factors
November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Singh, Pratiksha, Rutgers Health, Community Medical Center, Toms River, New Jersey, United States
- Kata, Priyaranjan, Rutgers Health, Community Medical Center, Toms River, New Jersey, United States
- Pandey, Sujata, Rutgers Health, Community Medical Center, Toms River, New Jersey, United States
- Valladares, Carlos, Rutgers Health, Community Medical Center, Toms River, New Jersey, United States
- Ang, Song Peng, Rutgers Health, Community Medical Center, Toms River, New Jersey, United States
- Iglesias, Jose I., Rutgers Health, Community Medical Center, Toms River, New Jersey, United States
Background
Abdominal Aortic Calcification (AAC) is a strong predictor of cardiovascular disease (CVD), which is affected by age. Gender, comorbidities, inflammation, smoking, phosphate and chloride levels, and the presence of chronic kidney disease (CKD). The exact mechanism of increased risk of AAC in CKD remains unclear, but bone and mineral metabolism and endothelial dysfunction are stipulated causes. With this in mind, we analyzed the NHANES database, which provided measurements of AAC.
Methods
3140 subjects from the NHANES 2013-2014 dataset were included in the analysis of 40 demographic, clinical, and laboratory variables that were evaluated using univariate and multivariate analysis. Variables found to be significantly associated with AAC were included in a stepwise forward logistic regression analysis. Additionally, K means cluster analysis was performed in 2,943 subjects.
Results
Severe AAC was present in 423 subjects (13%). Stepwise forward logistic regression analysis demonstrated that Caucasian race, older age, smoking, coronary artery disease, and hypertension were associated with increased risk of AAC. In contrast, higher eGFR and higher serum chloride were associated with decreased risk. K means cluster analysis identified 3 clusters, C1, C2, and C3, representing 61%, 1%, and 38% of subjects, respectively. Compared to C2 and C3, subjects in C1 had lower AAC, higher eGFR, a lower degree of proteinuria, lower neutrophile lymphocyte ratio (NLR), higher klotho levels, and younger age.
Conclusion
A higher eGFR is independently associated with reduced risk of AAC in individuals, even in the presence of traditional risk factors. In addition, several phenotypes can be classified mainly on renal function parameters, inflammation (lower NLR), higher Klotho levels, and glomerular injury. Early interventions to maintain eGFR in individuals with traditional risk factors may improve CVD outcomes.
Logistic Regression