Abstract: TH-PO208
The Characteristics of Myocardial Fibrosis and Analysis on Related Influencing Factors in Hemodialysis Patients
Session Information
- Hypertension and CVD: Clinical - I
November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Zhuang, Bing, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
- Luo, Yuan, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
- Wei, Guiling, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
- Ye, Hong, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
- Yang, Junwei, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background
This study aimed to analyze the characteristics of myocardial fibrosis and related influencing factors in hemodialysis patients, and to explore whether cardiovascular magnetic resonance (CMR) based on T1 mapping technique has prognostic value in predicting cardiovascular events.
Methods
This was a prospective observational study. The clinical data and dialysis parameters were collected, and laboratory tests were conducted. All patients underwent CMR, T1 mapping technique was used to identify myocardial interstitial fibrosis and LGE positive was used to identify alternative myocardial.
Results
A total of 42 hemodialysis patients were enrolled, the mean native T1 value of the entire heart was 1277.34±54.95ms. The native T1 value was positively correlated with heart rate and the ratio of transmitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity (E/e') (r=0.366, P=0.017; r=0.386, P=0.014), and negatively correlated with six-minute walk distance (r=-0.474, P=0.002). E/e' was found to be a risk factor for the mean native T1 value of the entire heart in hemodialysis patients (OR=1.508, 95% CI: 1.008-2.258, P=0.046). LGE scans were completed in 39 patients, of whom 12 (30.8%) were LGE positive and 27 (69.2%) were LGE negative. Compared with the LGE negative group, the LGE positive group had a shorter six-minute walk distance (P=0.029), larger left ventricular end-systolic volume (LVESV) and left ventricular mass (LVM) (P=0.023 and P=0.025, respectively). Left ventricular mass was found to be a factor influencing LGE positivity (OR=1.045, 95% CI: 1.003-1.088, P=0.035). Logistic regression analysis showed that the higher the native T1 value, the greater the probability of cardiovascular events occurring within six months (OR=1.1, 95% CI: 1.003-1.206, P=0.043).
Conclusion
E/e' is a factor influencing interstitial fibrosis in hemodialysis patients and the left ventricular mass is a factor influencing alternative fibrosis. The native T1 value has predictive value for cardiovascular events within six months.
Funding
- Government Support – Non-U.S.