Abstract: SA-PO1068
Association Between Pretransplant Dialysis Modality and Long-Term Graft Outcomes
Session Information
- Transplantation: Clinical - II
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Seo, Young Kyeong, Inje University Busan Paik Hospital, Busan, Korea (the Republic of)
- Kim, Taehee, Inje University Busan Paik Hospital, Busan, Korea (the Republic of)
- Kim, Yunmi, Inje University Busan Paik Hospital, Busan, Korea (the Republic of)
- Huh, Hyuk, Inje University Busan Paik Hospital, Busan, Korea (the Republic of)
- Kim, Yeong Hoon, Inje University Busan Paik Hospital, Busan, Korea (the Republic of)
Background
previous systemic reviews have shown that peritoneal dialysis (PD) is associated with substantial improvements in patient survival and delayed graft function compared with hemodialysis (HD) treatment as a pretransplant modality, the association between pretransplant dialysis modalities and posttransplant outcomes remains controversial.
Methods
We retrospectively collected records from 773 kidney transplant recipients between January 2008 and October 2021 in 2 transplant
centers. We excluded recipients under the age of 18, 2nd or 3rd transplant recipients, and preemptive recipients. The final analysis
included 558 kidney transplant recipients(fig. 1)We examined graft survival across pretransplant modality.
Results
558 kidney transplant recipients were 47.5 years old and included 42% females and 28% diabetes. 407 recipients underwent HD, and
151 recipients underwent PD before transplantation.
The overall graft survival between pretransplant HD and PD showed no statistical difference (P=0.197)(Fig. 2).
pretransplant HD seemed to be favorable for graft survival over a long-term follow-up period of over 10 years.
Conclusion
Pretransplant modalities during the transition to a kidney transplant are not associated with graft survival.
Table 1. baseline characteristics of 558 KT recipients
| All | HD | PD | P value | |
| Characteristics, N (%) | 558 | 407 | 151 | |
| Age | 47.5±11.8 | 48±11.5 | 46±12.5 | 0.214 |
| Female | 236 (42) | 167 (41) | 69 (46) | 0.322 |
| DM | 158 (28) | 127 (31) | 31 (21) | 0.02 |
| HBP | 82 (15) | 59 (15) | 23 (15) | |
| HBsAg | 40 (7) | 33 (8) | 7 (5) | 0.249 |
| CKD cause | 0.148 | |||
| DM | 132 (24) | 103 (25) | 29 (19) | |
| Hypertension | 82 (15) | 59 (15) | 23 (15) | |
| GN | 136 (24) | 91 (22) | 45 (30) | |
| PCKD | 24 (4) | 20 (5) | 4 (3) | |
| Others | 13 (2) | 11 (3) | 2 (1) | |
| Unknown | 164 (29) | 116 (29) | 48 (32) | |
| Relations | 0.609 | |||
| LD | 197 (35) | 141 (35) | 56 (37) | |
| DD | 359 (64) | 264 (65) | 95 (63) | |
| ABOi tranplant | 38 (7) | 30 (7) | 8 (5) | 0.183 |
| Waiting time, years | 4.5 (1.5, 7.4) | 4.5 (1.3, 7.7) | 4.4 (2.0, 6.8) | <0.001 |
| Rejection episode | 445 (80) | 330 (81) | 115 (76) | 0.021 |
LD, living donor; DD, deceased donor