Abstract: FR-PO781
Donor-Derived Human Herpes Virus-8 (HHV8)-Related Kaposi Sarcoma (KS) in Renal Allograft Following a Hepatitis C Virus (HCV)-Positive Kidney Transplantation
Session Information
- Post-Transplantation and Case Reports
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Jaiswal, Shikha, University of Cincinnati, Cincinnati, Ohio, United States
- Govil, Amit, University of Cincinnati, Cincinnati, Ohio, United States
- Patel, Niralee, University of Cincinnati, Cincinnati, Ohio, United States
- Zimmermann, Nives, University of Cincinnati, Cincinnati, Ohio, United States
- Cuffy, Madison, University of Cincinnati, Cincinnati, Ohio, United States
- Anand, Manish, University of Cincinnati, Cincinnati, Ohio, United States
Introduction
KS post Kidney transplantation can develop due to reactivation of recipient latent HHV8 infection, or donor acquired HHV8 infection. We describe a rare case of Donor derived HHV8 related KS involving the allograft, presenting as Acute kidney Injury.
Case Description
54-year-old female underwent kidney transplant from HCV positive deceased donor. Immunosuppression(IS) included Thymoglobulin followed by tacrolimus and mycophenolate (MMF). She was successfully treated for Donor-derived HCV infection with Sofosbuvir/Velpatasvir. Baseline serum creatinine was 1.4 mg/dl.
She developed CMV Viremia that responded well to reduced IS and valganciclovir. However, creatinine increased to 2.3mg/dl, and transplant biopsy was done to rule out rejection.
It showed foci of vascular proliferation, prominent mitoses, atypical cells with enlarged nuclei (Fig 1) and positive Immunostain for HHV8 (Fig2) indicating KS.
Her MMF was switched to Everolimus. She had no cutaneous lesions on exam and has been referred to Oncology.
Discussion
Increasing proportion of PHS high risk organ recipients are at risk for HHV8 infection and KS. To our knowledge only 8 cases of KS involving renal allograft have been described, with only 2 derived from HCV positive donors. With limited pre transplant testing of donors for HHV 8 infection, close monitoring of recipients with PHS high risk organs for KS is suggested.