Abstract: SA-OR68
The Association Between Potassium Intake and Risk of CKD
Session Information
- Nutritional and Lifestyle Interventions to Promote Health in CKD
November 04, 2023 | Location: Room 109, Pennsylvania Convention Center
Abstract Time: 04:30 PM - 04:39 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Kim, Hyo Jeong, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
- Koh, Hee Byung, Catholic Kwandong University International Saint Mary's Hospital, Incheon, Korea (the Republic of)
- Chang, Tae ik, National Health Insurance Service Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
- Rhee, Connie, University of California Irvine School of Medicine, Irvine, California, United States
- Kalantar, Diana Sunhee, University of California Irvine School of Medicine, Irvine, California, United States
- Kalantar-Zadeh, Kamyar, University of California Irvine School of Medicine, Irvine, California, United States
- Han, Seung Hyeok, Yonsei University Institute of Kidney Disease, Seodaemun-gu, Seoul, Korea (the Republic of)
Background
High dietary potassium intake is associated with lower risk of cardiovascular disease. However, the association between potassium intake and chronic kidney disease (CKD) development in the general population is uncertain.
Methods
From UK biobank cohort, we included 317,162 participants without CKD between 2006-2010. The main predictor was spot urine potassium-to-creatinine ratio (KCR) as a surrogate of potassium intake. The primary outcome was incident CKD, defined by ICD-10 and OPCS-4 codes. In secondary analyses, we examined dietary potassium intake as an additional predictor in 141,180 participants who completed 24-h dietary recall questionnaires.
Results
At baseline, individuals with higher KCR had lower levels of blood pressure, BMI, and inflammation were less likely to have diabetes and hypertension vs. those with lower KCR. During a median follow-up of 11.9 years, the primary outcome occurred in 15,255 (4.8%) participants. In cause-specific models, the adjusted hazard ratio (aHR) per 1-SD increase in KCR for incident CKD was 0.90 (95% confidence interval [CI], 0.89-0.92). In addition, compared with quartile (Q)1 of KCR, the aHRs (95% CIs) for Q2, Q3, and Q4 were 0.98 (0.94–1.02), 0.90 (0.86–0.95), and 0.80 (0.76–0.84), respectively. In secondary analyses, higher potassium consumption was also inversely associated with risk of CKD. Compared with Q1 of dietary potassium intake, the corresponding aHRs (95% CIs) for each Q were 0.85 (0.78–0.92), 0.73 (0.67–0.81), and 0.67 (0.60–0.75), respectively.
Conclusion
In this large-scale population-based cohort study, higher urinary potassium excretion and dietary potassium intake were significantly associated with a lower risk of incident CKD development. Our findings provide new insight into dietary interventions among healthy adults to prevent CKD development.
Table 1. HRs for the incident CKD outcomes according to spot urinary KCR and dietary potassium intake