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Kidney Week

Abstract: FR-PO901

The Association Between Oral Frailty and Physical Performance in Patients with CKD

Session Information

  • Geriatric Nephrology
    November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Geriatric Nephrology

  • 1300 Geriatric Nephrology

Authors

  • Jang, Kyu Won, Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of)
  • Koo, Bon Jin, Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of)
  • Kim, Do Kyun, Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of)
  • Kim, Seo Rin, Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of)
  • Ye, Byung Min, Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of)
  • Kim, Il Young, Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of)
  • Lee, Soo Bong, Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of)
  • Lee, Dong Won, Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of)
Background

Chronic kidney disease (CKD) is one of the major causes and exacerbating factors for sarcopenia. Patients with CKD frequently experience dry mouth due to water restriction and decreased appetite due to uremic toxins, which leads to malnutrition, protein-energy wasting, and increased mortality. The association between oral function and the sarcopenia index in CKD remains unclear. The purpose of this study was to evaluate the oral function and its correlation with the sarcopenia index in patients with CKD.

Methods

The participants were non-dialysis CKD patients (stage 3~5) who visited an outpatient clinic in a single center. Oral frailty was evaluated by the Oral Frailty Index-8 and physical examinations assessing the number of teeth, tongue-lip motor function, and tongue coating index. The sarcopenia index and the Frail Questionnaire were assessed.

Results

Among the 72 patients (49 males, 23 females; mean age 67.0±11.8 years; mean serum creatinine level 3.83±2.65 mg/dl), 55.6% of participants had oral frailty, defined as an Oral Frailty Index-8 score of 4 points or more. Male participants had higher serum creatinine levels than the female group (4.24±2.94 mg/dl vs. 2.96±1.67 mg/dl, respectively). Muscle strength measured by handgrip strength in the male group with oral frailty was lower than that without oral frailty (26.9±6.11 vs. 32.6±7.10kg, respectively, P=0.003), whereas there was a decreasing trend in the female group (15.1±4.72 vs. 19.5±5.77kg, respectively, P=0.06). Patients who have oral frailty showed decreased physical performance (with oral frailty 12.9±5.45s, vs. without oral frailty 8.89±3.05s, P<0.001). Oral frailty was linked with lower physical performance, according to the logistic regression analysis (OR 1.30, CI 1.097-1.546, P=0.003). In simple linear regression, the level of serum creatinine and the oral frailty score were associated (r=0.26, P=0.03).

Conclusion

Oral frailty is present in more than half of outpatients with non-dialysis CKD. This suggests the significance of managing physical performance early for CKD patients to avoid oral frailty. Additionally, muscle-strengthening exercises should be more crucial to prevent oral frailty as CKD progresses.