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Kidney Week

Abstract: TH-PO338

Association Between Prediabetes and Cardiovascular Mortality in Patients Treated with Peritoneal Dialysis: A Retrospective Study from Southern China

Session Information

  • Home Dialysis - I
    November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

  • 802 Dialysis: Home Dialysis and Peritoneal Dialysis

Authors

  • Qinghua, Hu, Shunde Hospital of Southern Medical University, Foshan, Guangzhou, China
  • Luo, Qimei, Shunde Hospital of Southern Medical University, Foshan, Guangzhou, China
  • Dou, Xianrui, Shunde Hospital of Southern Medical University, Foshan, Guangzhou, China
Background

The term prediabetes is used for individuals who have impaired glucose metabolism but the levels of glucose or HbA1c are not yet high enough to be diagnosed as diabetes.Prediabetes may already be associated with an increased risk of chronic diabetes-related complications in the general population.The present study was aimed to investigate the clinical impact of prediabetes on cardiovascular mortality in a population from southern of China who received peritoneal dialysis(PD) treatment.

Methods

Patients who received PD treatment above 3 months between January 2004 and December 2021 from four center were enrolled.The clinical record from last time before PD treatment were collected as baseline data.Prediabetes was defined as impaired fasting plasm glucose (FPG) according to the definition of the World Health Organization (WHO-prediabetes:6.1-6.9mmol/L).The association of baseline prediabets with cardiovascular mortality was evalued with multivariable Cox proportiona hazard analyses.We further performed subgroup analysis stratified by baseline characteristics including age(<47,≥47year),sex,smoking, hypertension status, PD vintage(<42,≥42months),hemoglobin(<83,≥83g/L),albumin(<36,≥36g/L),serum potassium(<2.0,≥2.0mmol/L).

Results

A total of 2045 PD patients were enrolled in this study.Of them,545 were(26.7%)diagnosed as diabetes,165(8.1%)were diagnosed as prediabetes according to IFG-WHO.During a median follow-up period of 42months,178(8.7%) patients occurred cardiovascular mortality,of which 95 of1335(7.1%)patients in the non-prediabetes group and 20 of 165(12.1%)patients in the WHO-prediabetes group. Adjusted Cox regression models showed that compared with non-prediabetes,patients diagnosed as WHO-prediabetes was associated with an increased risk of cardiovascular mortality(HR 1.80,95% CI,1.12-2.88)after adjusted for age,sex,smoking,hypertension status,PD vintage,hemoglobin,albumin etc.The inverse association between the prediabetes with cardiovascular mortality was stronger in patients without hypertension (P for interaction=0.013).

Conclusion

WHO-prediabetes is an independent risk factor for cardiovascular mortality in patients receiving PD treatment.