Abstract: FR-PO129
Magnesium Supplementation Is Associated with Reduced Mortality in AKI Requiring Continuous Kidney Replacement Therapy (CKRT)
Session Information
- AKI: Outcomes, RRT
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 102 AKI: Clinical, Outcomes, and Trials
Authors
- Matsuura, Ryo, The University of Tokyo Hospital, Tokyo, Japan
- Hamasaki, Yoshifumi, The University of Tokyo Hospital, Tokyo, Japan
- Nangaku, Masaomi, The University of Tokyo Hospital, Tokyo, Japan
- Doi, Kent, The University of Tokyo Hospital, Tokyo, Japan
Background
Hypomagnesemia is a common electrolytic disorder and associated with mortality and delayed renal recovery in AKI patients. Although prevention and treatment of hypomagnesemia are suggested, evidence that magnesium (Mg) supplementation could improve survival is still lacking.
Methods
We retrospectively collected the data on AKI patients requiring CKRT with the support of vasopressors and/or ventilators. After excluding patients without measurement of serum magnesium at the day of CKRT start and those who died within 48 hours from CKRT start, patients were divided in two groups according to presence or absence of Mg supplementation within 48 hours of CKRT. Propensity score matching was performed using a 2:1 nearest neighbor matching algorithm. The primary and secondary outcomes were mortality and KRT free at 90 days. The association with Mg supplementation and outcomes was evaluated using a multivariable Cox regression model and a Fine and Gray model.
Results
After excluding 296 patients who died within 48 hours or did not have measurement of serum Mg, 296 patients without and 37 with Mg supplementation were eligible. After propensity score matching, 68 patients without and 34 patients with Mg supplementation were analyzed. There is no difference in age, sex, presence of sepsis, baseline kidney function, illness severity and serum magnesium. Patients with Mg supplementation received 24.4±10.6mEq of Mg during 48 hours. The mortality rate was lower in patients with Mg supplementation than in those without (Figure). Mg supplementation is inversely associated with 90-day mortality with adjusted hazard ratio of 0.38 (95%CI, 0.18 – 0.83). Mg supplementation was associated with KRT free at 90 days with hazard ratio of 2.07 (95%CI, 1.23–3.49).
Conclusion
The study using propensity score matching revealed the association of Mg supplementation with improving survival rate and renal recovery.
Kaplan-Meier Survival Curve