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Abstract: FR-PO396

HIF-1α/mTOR/REDD1 Pathway Modulates the Effect of Adipose Tissue-Derived Stem Cells on Kidney Disease Progression in Spontaneously Hypertensive Rats (SHRs) with Induced Visceral Obesity

Session Information

  • Hypertension and CVD: Basic
    November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

  • 1601 Hypertension and CVD: Basic


  • Batista, Marcelo Costa, Universidade Federal de Sao Paulo, São Paulo, Sao Paulo, Brazil
  • Nakamichi, Renata, Universidade Federal de Sao Paulo, São Paulo, Sao Paulo, Brazil
  • Quinto, Beata M r, Universidade Federal de Sao Paulo, São Paulo, Sao Paulo, Brazil

The aim of this study was to determine the effect of adipose tissue-derived stem cells (ASC) on the development of renal disease in spontaneously hypertensive rats (SHRs) fed a hypercaloric diet and if their altered lipid profile was dependent on the mTOR/HIF-1α/REDD1 pathway.


SHRs were divided into groups that received a standard or high-fat diet for 12 weeks and were later treated with ASC for 1 or 2 weeks. Lipid profile and kidney function were evaluated, as well as, the expression and production of the adipocytokines TNF-α, HIF-1α,mTOR and REDD1.


A high-fat diet given to SHRs caused changes in glucose and lipid profiles resulting in insulin resistance, increase in serum levels of triglycerides and low-density lipoprotein cholesterol and decrease in high-density lipoprotein cholesterol values. We also observed an increase in the production of leptin and TNF-α and a reduction in adiponectin, with simultaneous increase in the expression of HIF-1α, mTOR and REDD1 in kidney tissue. Treatment with ASC resulted in the reversal of the kidney and metabolic dysfunction promoted by high-fat diet, with improved glucose and lipid profiles, improved renal function and reduced visceral HIF-1α, mTOR and REDD1 as well.


We found that treatment with ASC resulted in reversal of inflammatory-related kidney damage and metabolic imbalance in SHRs fed a high-fat diet.


  • Government Support – Non-U.S.