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Abstract: SA-PO568

The Relationship Between Myocardial Fibrosis and Physical Activity in Individuals Receiving Hemodialysis

Session Information

Category: Dialysis

  • 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • March, Daniel Scott, University of Leicester, Leicester, United Kingdom
  • Hull, Katherine Leigh, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
  • Graham-Brown, Matthew, University of Leicester, Leicester, United Kingdom
  • Burton, James, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom

Group or Team Name

  • On Behalf of the CYCLE-HD Investigators.
Background

Individuals with end stage kidney disease receiving haemodialysis have high levels of myocardial fibrosis, which is thought to contribute to their excess cardiovascular burden. In addition, these individuals are physically inactive, which directly associates with high levels of cardiovascular and all-cause mortality. However, the relationship between physical activity levels and myocardial fibrosis has not previously been explored.

Methods

This is a post-hoc analysis of baseline data from the CYCLE-HD trial. Participants wore an accelerometer on the upper arm for 7 days; average steps per day were calculated by dividing the total number of steps by days worn. Global, septal and non-septal native T1 times (a surrogate of myocardial fibrosis) were acquired using cardiac MRI. Spearman’s correlation and multiple linear regression analyses (adjusting for age, gender and diabetes) were performed to investigate associations between steps per day and T1 variables.

Results

Data for 102 participants were included. Mean steps per day were 3180±282. Steps per day had a significant negative correlation with global native T1 (-0.308; P = 0.002), non-septal T1 (-0.287; P = 0.004) and septal T1 (-0.275; P = 0.005). This relationship persisted after adjustment (Table 1).

Conclusion

Increased physical activity defined by average daily step count, associates with lower levels of myocardial fibrosis. Overall the levels of physical activity were low (comparable to levels reported in other studies), however these data indicate that even these levels (below recommended guideline levels) may be beneficial. Longitudinal studies are needed to understand the mechanisms behind these findings.

Table 1. Multiple linear regression showing the association between steps per day, Native T1, Non-septal T1 and Septal T1
 Standardised coefficients β (95% CI)P-value
Steps per day and CMR (n=102) 
Native T1-0.004 (-0.007 to -0.001)=0.003
Non-septal T1-0.004 (-0.006 to -0.001)=0.009
Septal T1-0.004 (-0.007 to -0.001)=0.007

*There was no significant association between myocardial fibrosis and other variables (age, gender and diabetes) in the regression analyses.