Kidney Week

Abstract: TH-PO1011

Prevalence and Progression of Kidney Diseases Among Ethiopian Immigrants Compared with Other Immigrant and Native Populations in Israel

Session Information

• CKD Epidemiology, Risk Factors, Prevention - I
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Einbinder, Yael, Meir Medical Center, Kfar Saba, Central, Israel

Yael Einbinder,

• Hornik-Lurie, Tzipi, Meir Medical Center, Kfar Saba, Central, Israel

Tzipi Hornik-Lurie,

• Cohen - Hagai, Keren, Meir Medical Center, Kfar Saba, Central, Israel

Keren Cohen - Hagai,

• Benchetrit, Sydney, Meir Medical Center, Kfar Saba, Central, Israel

Sydney Benchetrit,

• Karpati, Tomas, Holon Institute of Technology, Holon, Israel

Tomas Karpati,

Background

The worldwide prevalence of kidney disease in the Ethiopian population is unknown. This study assessed the prevalence of CKD and risk-factors for progression among Ethiopian immigrants compared to Soviet Union immigrants, as well as Israeli-born Jewish and Arab population.

Methods

The study included all people above 25 years old who were insured by Clalit Health Services from 01/01/2007 until 31/12/2017, and had more than two plasma creatinine measurements at least 28 days apart, which demonstrated similar CKD stage. Follow-up was until 31/12/2020. Primary outcome was at least 50% decrease in estimated glomerular filtration rate (eGFR) calculated with CKD-epi equation. Cox regression model was used to analyze risk-factors for CKD progression.

Results

The study included 1,734,501 people, of whom 41,260 (2.4%) were Ethiopian immigrants, mean age 44.8±16.6 years, baseline eGFR 111.1±16.5 ml/min/1.73m²; 273,476 (15.8%) former Soviet Union immigrants, mean age 56.3±18.1 years, baseline eGFR 88.2±22.5 ml/min/1.73m²; 366,789 (21.1%) native Israeli Arabs, mean age 42.5±14.5 years, baseline eGFR 107.9±18.8 ml/min/1.73m², and 1,052,976 (60.7%) native Israeli Jews, mean age 43.1±14.3 years, baseline eGFR 102.6±18.7 ml/min/1.73m². (p<0.001 for age and eGFR). Decrease in eGFR ≥50% was documented in 38,913 (2.2%) people: 573 (1.4%) were Ethiopian immigrants. Cox regression model was performed in three age groups: Ethiopian ethnicity was associated with higher risk for CKD progression in the young group (<50 years), HR 1.70 (95% CI: 1.54-1.90, p <0.001), but had no effect in the 50 to 70 years age group, HR 1.14 (95% CI: 1.05-1.24, p =0.098) and had a protective effect in the older, ≥70 years group, HR 0.62 (95% CI: 0.57-0.68, p <0.001).

Conclusion

Young Ethiopian immigrants had higher risk for CKD progression which was absent among older Ethiopian immigrants, suggesting a genetic/familial etiology or adaptive factors. Further research is desirable.