Kidney Week

Abstract: TH-PO231

Ideal Cardiovascular Health and CKD Progression in Hispanic Adults

Session Information

• Hypertension and CVD: Clinical - I
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1602 Hypertension and CVD: Clinical

Authors

• Madero, Magdalena, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico

Magdalena Madero,

• Ricardo, Ana C., University of Illinois Chicago, Chicago, Illinois, United States

Ana C. Ricardo,

• Fernandez Yepez, Ana K., Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico

Ana K. Fernandez Yepez,

• Carmona, Eunice, University of Illinois Chicago, Chicago, Illinois, United States

Eunice Carmona,

• Sacal Saba, Karen, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico

Karen Sacal Saba,

• Alvarez Vallejo, Jose Manuel, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico

Jose Manuel Alvarez Vallejo,

• Cabrera Castelán, Sara, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico

Sara Cabrera Castelán,

• Ramírez Santamaria, Ana Lucero, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico

Ana Lucero Ramírez Santamaria,

• Meza, Natalie, University of Illinois Chicago, Chicago, Illinois, United States

Natalie Meza,

• Larkin, Claire T., University of Illinois Chicago, Chicago, Illinois, United States

Claire T. Larkin,

• Missikpode, Celestin, University of Illinois Chicago, Chicago, Illinois, United States

Celestin Missikpode,

• Lash, James P., University of Illinois Chicago, Chicago, Illinois, United States

James P. Lash,

Background

The American Heart Association developed the Life’s Simple 7 metric to promote cardiovascular health. We evaluated the association of this metric with chronic kidney disease (CKD) progression among Hispanic individuals with CKD.

Methods

We conducted a prospective observational cohort study of 663 adults with CKD enrolled in the Mexico and Hispanic Chronic Renal Insufficiency Cohorts (HCRIC and MCRIC), with entry estimated glomerular filtration rate (eGFR) 20-70 ml/min/1.73 m². Ideal levels of Life’s Simple 7 (score range 0-14) were the following: nonsmoker; body mass index <25 kg/m²; ≥150 minutes/week of physical activity; healthy dietary pattern (high in fruits and vegetables, fish, and fiber-rich whole grains; low in sodium and sugar-sweetened beverages); total cholesterol <200 mg/dL; blood pressure <120/80 mm Hg; and fasting blood glucose <100 mg/dL). The primary outcome was CKD progression defined as 30% and 40% decline in eGFR from baseline. Cox proportional hazards regression analyses were used.

Results

At study entry, mean (SD) age was 56 (12) years, 238 (36%) were female, and 408 (62%) had diabetes. Mean (SD) baseline eGFR was 45 (17) ml/min/1.73m², and median (IQR) urine protein excretion was 0.6 (0.1-2.6) g/24 hours. The median (IQR) Life’s Simple 7 score was 7 (6-9) points, and 47% of participants had ideal or intermediate cardiovascular health (score 8-14 points). During a median follow-up of 3.4 years, there were 415 (63%) and 341 (51%) CKD progression events for 30 and 40% eGFR decline, respectively. In analyses adjusted for age, sex, education, and baseline eGFR and proteinuria, each point higher Life’s Simple 7 score was associated with 10-12% lower risk of 30% and 40% eGFR decline (HR, 95% CI, 0.90,0.85-0.94 and 0.88, 0.84-0.93), respectively.

Conclusion

In this cohort of Hispanic adults with CKD, the prevalence of ideal cardiovascular health was low. Higher Life simple 7 score was associated with reduced risk for CKD progression.