Kidney Week

Abstract: TH-PO419

Applicability of Mayo's Autosomal Dominant Polycystic Kidney Disease Prognostic Tool in the Southeast Asian ADPKD Population

Session Information

• Genetic Diseases: Cystic - Therapeutic Investigations and Prognosis
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidneys

• 1201 Genetic Diseases of the Kidneys: Cystic

Authors

• Gan, Chye Chung, University of Malaya Faculty of Medicine, Kuala Lumpur, Wilayah Persekutuan, Malaysia

Chye Chung Gan,

• Goh, En Thong, University of Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan, Malaysia

En Thong Goh,

• Ooi, Shok Hoon, University of Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan, Malaysia

Shok Hoon Ooi,

• Leong, Wai Ling, University of Malaya Faculty of Medicine, Kuala Lumpur, Wilayah Persekutuan, Malaysia

Wai Ling Leong,

• Cheah, Peng Loon, University of Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan, Malaysia

Peng Loon Cheah,

• Vijayananthan, Anushya, University of Malaya Faculty of Medicine, Kuala Lumpur, Wilayah Persekutuan, Malaysia

Anushya Vijayananthan,

• Lim, Soo Kun, University of Malaya Faculty of Medicine, Kuala Lumpur, Wilayah Persekutuan, Malaysia

Soo Kun Lim,

Background

Mayo autosomal dominant polycystic kidney disease (ADPKD) prognostic tool revolved around the height-adjusted total kidney volume (HtTKV₀) measurement using MRI at a single point of time adjusted with age₀ and it was recognized as a strong predictor for kidney disease progression in patients with ADPKD. This study reports 24-month prospective longitudinal studies examining the applicability of the Mayo ADPKD prognostic tool in the Southeast Asian cohort in a tertiary center in Malaysia.

Methods

Convenience sampling was completed on March 2021. Patients were subjected to a single non-contrasted T2W-MRI kidney scan using the ellipsoid method with subsequent yearly blood samples collected for analysis. Total kidney volume₀ (TKV₀) was measured by 2 radiologists and the average of 2 results was recorded. Correlation of glomerular filtration rate generated from the Mayo ADPKD prognostic tool (eGFR_Mayo) and serum estimated glomerular filtration rate of patients according to 2009 CKD-EPI_creatinine (eGFR_2009CKD-EPI) were tested with Spearman correlation coefficient and Bland-Altman analysis.

Results

A total of 50 patients were enrolled with a median age of 39.5 years (33.5, 58.0) and predominantly female (54%), and of Chinese (60%) ethnicity. Median TKV₀ was 1233.8cm³ (697.2, 1995.8) and HtTKV₀ was 727.9ml/m (447.0, 1180.9). Three patients dropped out at month 24. eGFR_Mayo correlated very strongly with eGFR_2009CKD-EPI during the 24 months study with R_S0=1.000 (bias of -0.196, precision=0.395), R_S12=0.972 (bias of -0.204, precision=8.300), and R_S24=0.952 (bias of 4.670, precision=10.930) respectively, p<0.001. eGFR_Mayo demonstrated an accuracy of 42.6 – 98% within 10mls/min/1.73m² of serum eGFR_2009CKD-EPI.

Conclusion

Mayo's ADPKD prognostic tool demonstrated its applicability to the Southeast Asian ADPKD population with a very strong correlation to eGFR_2009CKD-EPI, low bias, and high precision. Long-term data with a larger sample size needs to be evaluated in future studies.

Spearman correlation coefficient & Bland-Altman analysis

*Web app by Mayo Foundation & Medical Education & Research

Funding

• Government Support – Non-U.S.