Kidney Week

Abstract: SA-OR74

Dietary Inflammatory Potential and Kidney Function in the Hispanic Community Health Study/Study of Latinos

Session Information

• Nutritional and Lifestyle Interventions to Promote Health in CKD
  November 04, 2023 | Location: Room 109, Pennsylvania Convention Center
  Abstract Time: 05:24 PM - 05:33 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1500 Health Maintenance, Nutrition, and Metabolism

Authors

• Johns, Tanya S., Albert Einstein College of Medicine, Bronx, New York, United States

Tanya S. Johns, MD, MS, FASN

• Mattei, Josiemer, Harvard University T H Chan School of Public Health, Boston, Massachusetts, United States

Josiemer Mattei,

• Estrella, Michelle M., University of California San Francisco, San Francisco, California, United States

Michelle M. Estrella,

• Sotres-Alvarez, Daniela, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Daniela Sotres-Alvarez,

• Daviglus, Martha L., University of Illinois Chicago, Chicago, Illinois, United States

Martha L. Daviglus,

• Mossavar-Rahmani, Yasmin, Albert Einstein College of Medicine, Bronx, New York, United States

Yasmin Mossavar-Rahmani,

• Melamed, Michal L., Albert Einstein College of Medicine, Bronx, New York, United States

Michal L. Melamed,

Background

Inflammation is implicated in the pathogenesis and progression of CKD. Diet modulates chronic inflammation and possibly kidney health. We evaluated the association of diet-related inflammation and kidney function among US Hispanic/ Latino adults.

Methods

Data were from participants in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a population-based study of Hispanic/Latino adults 18-74 years old from 4 US communities, who were examined at visit 1 (V1) (2008-2011) and visit 2 (V2) (2014-2017) and had data on dietary intake and serum creatinine. Dietary inflammatory potential was assessed using the dietary inflammatory index (DII^®). Scores were adjusted for total energy intake (E-DII^®) and categorized into tertiles: T1 having the lowest dietary inflammatory potential, and T3 having the highest (most pro-inflammatory). Creatinine-based eGFR was calculated using the 2021 CKD-Epi equation. Primary outcomes were incident CKD (eGFR <60 ml/min/1.73m² at V2 and ≥25% eGFR decline from V1 to V2) and rapid kidney function decline (RKFD) (≥30% decline in eGFR from V1 to V2). We excluded participants with eGFR <15 ml/min/1.73m², and for incident CKD, those with eGFR <60 ml/min/1.73m² at V1. Logistic regression models adjusting for study center and baseline socio-demographics, comorbidities, behavioral factors, medications, anthropometric measures, eGFR and albuminuria were used to compare E-DII^® tertiles and determine odds ratio for incident CKD and RKFD.

Results

Of 10,574 participants, median age was 49 years, 22% had diabetes, 46% had hypertension. Median eGFR was 101.7 ml/min/1.73m². Median E-DII^® was 0.18 (IQR -1.06 to 1.30). Over a mean follow-up of 6 years, 122 incident CKD and 196 RKFD events occurred. Participants with the most pro-inflammatory dietary patterns compared to the lowest had 2.2-fold higher odds of incident CKD (95% CI: 1.14 – 4.31) after adjusting for covariates. The E-DII^® was not significantly associated with RKFD.

Conclusion

A pro-inflammatory dietary pattern is associated with a higher likelihood of incident CKD among US Hispanic/ Latino adults. To prevent kidney disease, US Hispanic/ Latino adults may opt to reduce intake of foods with higher pro-inflammatory potential (e.g., processed or fried foods, red meat, sweetened beverages).

Funding

• NIDDK Support