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Kidney Week

Abstract: TH-PO951

A Retrospective View of the Relationship of Soluble Fas with Anemia and Outcomes in CKD

Session Information

Category: Anemia and Iron Metabolism

  • 200 Anemia and Iron Metabolism

Authors

  • Andrade, Jessica Liara Felicio de, Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Clemente, Otavio Henrique, Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Silva, Beatriz Moreira, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  • Rodrigues, Adelson, Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Zarjou, Abolfazl, The University of Alabama at Birmingham Center for the Study of Community Health, Birmingham, Alabama, United States
  • Goes, Miguel Angelo, Sociedade Beneficente Israelita Brasileira Albert Einstein, Sao Paulo, São Paulo, Brazil
Background

Anemia is common in chronic kidney disease (CKD) and is related to serum levels of soluble Fas (sFas), which are associated with resistance to erythropoietin (EPO). The study objeticves to compare clinical data and serum levels of sFas, EPO, and pro- inflammatory markers between non-dialytic CKD patients and healthy individuals. To assess the relationship of serum EPO and sFas between these patients with and without anemia.

Methods

Retrospective study of 58 CKD patients under conservative treatment and 20 healthy individuals. Complete blood count, renal function, serum EPO, sFas, and inflammatory markers (CRP, IL-6, and IFN-γ) were compared at baseline. We then analyzed these variables between patients who progressed to anemia and those without anemia. We evaluated the frequency of outcomes in these patients with elevated sFas levels. We performed a multivariate analysis of factors associated with anemia.

Results

CKD when compared to healthy individuals had lower eGFR (35.7 ±2.5 vs 89.7 ±3.32 ml/min; p<0.001), and Hb (12.8 ±0.27 vs 14.4 ± 0.25 g/dl; p=0.003), major inflammatory markers, sFas (2894 ±172 vs 1136 ±97pg/ml; p<0.001), and EPO/Hb (8.76 ±1.16 vs 4.90 ± 0.58 IU/mg/dl; p=0.003). CKD with anemia, when compared to non-anemic individuals, had lower eGFR (27.7 ±1.72 vs 54.9 ±5.26; p<0.001) and higher sFas/ eGFR (150.9 ±16.6 vs 45.2 ±9.95; p<0.001), EPO/Hb (10.3 ±1.56 vs 5.12 ±0.69; p=0.04) and sFas (3339 ±181 vs 1820 ±240; p=0.001). We found an independent association in the multivariate analysis of serum sFas levels with long-term renal anemia sFas (OR 4.322, 95% CI, 1464-12.753; p=0.008).

Conclusion

As an elective risk factor, serum sFas levels were independently associated with long-term renal anemia.

Funding

  • Other NIH Support