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Kidney Week

Abstract: SA-PO818

Decreased Kidney Volume Is Associated with AKI

Session Information

Category: Genetic Diseases of the Kidneys

  • 1202 Genetic Diseases of the Kidneys: Non-Cystic

Authors

  • Sosa, Piera A., Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Triozzi, Jefferson Lorenzo, Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Robinson-Cohen, Cassianne, Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Siew, Edward D., Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Hung, Adriana, VA Tennessee Valley Healthcare System, Nashville, Tennessee, United States
Background

Decreased kidney volume may increase glomerular filtration and nephron workload, potentially increasing the risk of acute kidney injury (AKI). However, the mechanisms of this relationship are unclear. In this study, we investigated the relationship between kidney volume, as measured by MRI, and AKI using Mendelian randomization (MR).

Methods

We performed a two-sample MR experiment using genome-wide summary statistics for kidney volume as the exposure from the UK Biobank (n = 32,860) and AKI as the outcome from the FinnGen Consortium (n = 2,383 cases, n = 212,841 controls). The inverse variance weighted (IVW) analysis was the primary outcome, and the weighted median, weighted mode, and MR-Egger regression were sensitivity analyses. Heterogeneity and pleiotropy were tested.

Results

An association between kidney volume and acute kidney injury was observed in the IVW analysis (β = -0.89, SE = 0.28, p = 0.0012) and supported in the weighted median (β = -1.054, SE = 0.30 , p = 0.00055), weighted mode (β = -1.36 , SE = 0.53, p = 0.031), and MR Egger regression analyses (β = -4.18, SE = 1.44, p = 0.020). There was no heterogeneity (IVW Q-statistic p = 0.16, MR Egger Q-statistic p = 0.47) but possible horizontal pleiotropy (MR Egger regression intercept p = 0.049). Ten SNPs were analyzed, of which six are related with anthropomorphic features, including body height and waist-hip ratio.

Conclusion

Kidney volume may have a causal effect on acute kidney injury. Larger kidney volume may protect against acute kidney injury. Some of the involved genes relate to anthropomorphic features, such as PTCH1. Further investigation is warranted to understand the mechanisms of this relationship and the role of the genes involved.

Mendelian Randomization of Kidney Volume and Acute Kidney Injury

Funding

  • Veterans Affairs Support