Kidney Week

Abstract: TH-PO210

Relationship Between Pulse Wave Velocity and Nocturnal Blood Pressure in Hypertensive Subjects: A Retrospective Study

Session Information

• Hypertension and CVD: Clinical - I
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1602 Hypertension and CVD: Clinical

Authors

• Abdalla, Marwa, MedStar Georgetown University Hospital, Washington, District of Columbia, United States

Marwa Abdalla,

• Daneshmand, Arvin, University of Florida, Gainesville, Florida, United States

Arvin Daneshmand,

• Pourafshar, Negiin, MedStar Georgetown University Hospital, Washington, District of Columbia, United States

Negiin Pourafshar,

Background

Tonometric pulse wave velocity (PWV) has been established as a non-invasive method for assessment of arterial stiffness¹. Arterial stiffness as measured by PWV is an emerging tool for Cardiovascular risk evaluation and stratification²; as in hypertensive patients, elevated PWV could be associated with an increased risk of cardiovascular death³. The purpose of this study was to assess the relationship between nocturnal blood pressure (BP) decline and PWV in the hypertensive subjects.

Methods

This is a retrospective study of patients who underwent ambulatory blood pressure monitoring between April 2021 and June 2022 at Medstar Georgetown University Hospital. Fifty-two subjects with essential hypertension were included. BP was measured by ambulatory monitoring every 30 min between 06:00 am and 22:00 pm and every 30 min at night, throughout 48 hours with a Mobil-o-graph device. Carotid-femoral PWV was also measured as an index of aortic stiffness, by using the Mobil-o-graph which uses a validated transfer function.

Results

Among the 52 subjects, 42% were female, 58% were male, and the average age range was 64 years old. Forty-eight hour systolic/diastolic BP were 127.9 (± 13.1)/77.8 (± 10.7) mmHg, mean nocturnal BP was 119.1 (± 15.1)/ 70.3 (± 11.9) mmHg and nocturnal BP changes was -8.5 (± 10.2)/-12.2 (± 11.3) mmHg. Among subjects, 40.3% of were dipper, 9.6% were extreme dipper, and 50% were non-dipper. Mean PWV was 8.2 m/sec. Nocturnal systolic BP had a significant correlation with PWV (r=0.72; p=0.000). No significant correlation was observed between PWV and diurnal BP.

Conclusion

Nocturnal blood pressure may assist physicians in identifying hypertensive subjects with higher arterial stiffness, who are at higher cardiovascular risk. Further studies are needed to assess advantages of lowering nocturnal blood pressure. Ambulatory blood pressure monitoring could be useful to appropriately evaluate cardiovascular risk in hypertensive subjects.