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Kidney Week

Abstract: TH-PO653

Clinical Characteristics and Risk Factors Analysis on a Cluster of Patients with Acquired Solitary Kidney

Session Information

Category: Glomerular Diseases

  • 1402 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Jing, Zhou, Wuhan University Renmin Hospital, Wuhan, Hubei, China
  • Wang, Huiming, Wuhan University Renmin Hospital, Wuhan, Hubei, China
Background

Patients with acquired solitary kidney (ASK), including those who underwent unilateral nephrectomy and those presented with non-functional unilateral kidney atrophy due to acquired causes. While the long term outcome of ASK patients remains an issue of debate. The aim of this study was to observe the clinical characteristics of ASK patients and identify the risk factors for poor prognosis.

Methods

We performed a retrospective analysis on a case series of ASK patients once hospitalized in Renmin Hospital of Wuhan University, China, from January, 2011 to November, 2022. Preoperative and postoperative clinical and demographic data were collected until last admission, Univariate and multivariate Logistic regression models were used to analyze the risk factors for patients with postoperative eGFR <60 mL/min. Kaplan–Meier cumulative prevalence curves were used to compare the incidence of ESRD in different groups of ASK patients.

Results

1. We enrolled 336 ASK patients in this study. Among them, 220 (65.5%)cases underwent unilateral nephrectomy due to hydronephrosis126 (37.5%) or renal cancer 94 (28.0%), the rest 116 (34.5%) patients were with unknown causes. The median age at diagnosis was 51.50 years old (IQR 42.02, 62.00), and after the median follow-up time of 6 years (IQR 3,12.75), the prevalence of hypertension, diabetes, anemia, hyperuricemia, hematuria and proteinuria were 43.8%, 15.7%, 40.8%, 37.8%, 71.1% and 44.3%, respectively.
2. K-M survival curve showed that ASK patients with hypertension, hyperuricemia, anemia, age at diagnosis ≥60 years, U-TP>2g/d were more likely to progress to ESRD .
3.Multivariate logistic regression analysis showed the risk factors which independently associated with the decreased eGFR including the age at diagnosis ≥60 years, follow-up time >10 years, hypertension, anemia, hyperuricemia, U-TP>2g/d, contralateral kidney operation history .

Conclusion

In conclusion, the ASK patients with underlying comorbidities, appears to be more susceptible in the long-term. It is particularly significant to have a strict and routine follow-up for ASK patients in high-risk .