ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

Abstract: TH-PO899

Pre-Transplant Biomarkers of Cellular Senescence Are Associated with Death with Function After Kidney Transplantation

Session Information

Category: Transplantation

  • 2102 Transplantation: Clinical

Authors

  • Lorenz, Elizabeth C., Baylor College of Medicine, Houston, Texas, United States
  • Bentall, Andrew J., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Smith, Byron H., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Park, Walter, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Hickson, LaTonya J., Mayo Clinic in Florida, Jacksonville, Florida, United States
  • Rule, Andrew D., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Lebrasseur, Nathan, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Stegall, Mark D., Mayo Clinic Minnesota, Rochester, Minnesota, United States
Background

Cellular senescence has associated with aging and medical risk in non-transplant populations. The goal of this study was to examine the relationship between pre-transplant biomarkers of cellular senescence and death with function after kidney transplantation.

Methods

We conducted a prospective, observational cohort study involving consecutive adult patients who received a kidney transplant at Mayo Clinic in Minnesota between 1/2006 and 12/2018. We measured biomarkers of cellular senescence in pre-transplant serum. Cox analyses, Kaplan Meier survival analyses, and gradient boosting machine modeling were used to examine the relationship between biomarkers and death with function after kidney transplantation.

Results

Our cohort consisted of 1,595 kidney transplant recipients, of whom 62.9% were male and 83.2% were non-Hispanic white. Over a mean follow-up time of 7.4 ± 3.9 years, 19.7% of patients (n=315) experienced death with function. Higher levels of growth differentiation factor-15 (GDF-15), interleukin-6 (IL-6), monokine induced by gamma interferon (MIG), and soluble tumor necrosis factor receptor-1 (sTNF-R1) were associated with death with function. Adding these biomarkers to a clinical Cox model improved the C-statistic for death with function from 0.732 to 0.750, while using a gradient boosting machine modeling approach instead improved the C-statistic to 0.768.

Conclusion

Pre-transplant biomarkers of cellular senescence predict death with function after kidney transplantation. Measuring serum concentrations of GDF-15, IL-6, MIG, and sTNF-R1 may help risk stratify kidney transplant candidates.

Funding

  • NIDDK Support