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Abstract: SA-PO729

Comparison of Local, Regional, and National Annual Trends of Hyponatremia Prevalence Rates in Hospitalized Patients

Session Information

Category: Fluid, Electrolytes, and Acid-Base Disorders

  • 1102 Fluid, Electrolyte, and Acid-Base Disorders: Clinical


  • Nawaz, Iqra, Stony Brook University, Stony Brook, New York, United States
  • Mallipattu, Sandeep K., Stony Brook University, Stony Brook, New York, United States

Hyponatremia is the most common electrolyte abnormality among hospitalized patients. A high prevalence of hyponatremia among patients with COVID-19 has been reported in the literature. However, there is a paucity of data assessing hyponatremia's prevalence rates in the pre-and post-COVID-19 pandemic period.


We used the TriNetX database (Stony Brook healthcare and the US- network (52 organizations)) to identify adults with hyponatremia (Na <135mmol/L) and normal-natremia (Na 135-145mmol/L) within the first 24hrs of inpatient or ED visit from Jan 1, 2015, to Dec 31, 2022.


Hyponatremia prevalence was 14% (40,570) in the SBUH cohort (298,130) and 19% (3,066,241) in the US cohort (16,395,015), respectively. Hyponatremia rates increased from 10% (4070) to 18% (6510) in the SBUH cohort, as compared to 16% (371,257) to 20% (460121) in the US cohort from 2019 to 2022. The rise of hyponatremia rates was 15% to 21% in SBUH in COVID +ive group compared to 7% to 10% in COVID -ive group from 2019 to 2021. Hyponatremia rates increased regionally from 2019 to 2022, with the highest rates of 22% and 20% noted among the Northeast and South regions in 2020. Hyponatremia among COVID-19 patients was associated with a significantly higher risk of ICU admissions, mechanical ventilation, and death.


Hyponatremia rates have been increasing locally, regionally, and nationally since 2019. Relatively higher prevalence rates were seen during the 2019-2021 period but were higher in both COVID-19 +ive and COVID-19 -ive groups, with a notably higher rise in hyponatremia rates among patients with COVID-19.

 COVID +ive Hyponatremia (Na <135) n(5030)COVID+Normonatremia(Na 135-145 mmol/L) n(15,830)Hazard ratio(CI)
Death1030(20%)1900(12%)1.76(1.593 1.828) p < 0.001
Mechanical Ventilation710(14%)1340(8.4%)1.6(1.531 1.1816) p < 0.003
ICU admissions1570(31%)2870(18%)1.7(1.6,33 1.815)p <0.001