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Abstract: SA-PO729

Comparison of Local, Regional, and National Annual Trends of Hyponatremia Prevalence Rates in Hospitalized Patients

Session Information

Category: Fluid, Electrolytes, and Acid-Base Disorders

  • 1102 Fluid, Electrolyte, and Acid-Base Disorders: Clinical

Authors

  • Nawaz, Iqra, Stony Brook University, Stony Brook, New York, United States
  • Mallipattu, Sandeep K., Stony Brook University, Stony Brook, New York, United States
Background

Hyponatremia is the most common electrolyte abnormality among hospitalized patients. A high prevalence of hyponatremia among patients with COVID-19 has been reported in the literature. However, there is a paucity of data assessing hyponatremia's prevalence rates in the pre-and post-COVID-19 pandemic period.

Methods

We used the TriNetX database (Stony Brook healthcare and the US- network (52 organizations)) to identify adults with hyponatremia (Na <135mmol/L) and normal-natremia (Na 135-145mmol/L) within the first 24hrs of inpatient or ED visit from Jan 1, 2015, to Dec 31, 2022.

Results

Hyponatremia prevalence was 14% (40,570) in the SBUH cohort (298,130) and 19% (3,066,241) in the US cohort (16,395,015), respectively. Hyponatremia rates increased from 10% (4070) to 18% (6510) in the SBUH cohort, as compared to 16% (371,257) to 20% (460121) in the US cohort from 2019 to 2022. The rise of hyponatremia rates was 15% to 21% in SBUH in COVID +ive group compared to 7% to 10% in COVID -ive group from 2019 to 2021. Hyponatremia rates increased regionally from 2019 to 2022, with the highest rates of 22% and 20% noted among the Northeast and South regions in 2020. Hyponatremia among COVID-19 patients was associated with a significantly higher risk of ICU admissions, mechanical ventilation, and death.

Conclusion

Hyponatremia rates have been increasing locally, regionally, and nationally since 2019. Relatively higher prevalence rates were seen during the 2019-2021 period but were higher in both COVID-19 +ive and COVID-19 -ive groups, with a notably higher rise in hyponatremia rates among patients with COVID-19.

 COVID +ive Hyponatremia (Na <135) n(5030)COVID+Normonatremia(Na 135-145 mmol/L) n(15,830)Hazard ratio(CI)
Death1030(20%)1900(12%)1.76(1.593 1.828) p < 0.001
Mechanical Ventilation710(14%)1340(8.4%)1.6(1.531 1.1816) p < 0.003
ICU admissions1570(31%)2870(18%)1.7(1.6,33 1.815)p <0.001