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Abstract: TH-PO496

Risk of Target Organ Damage in Pediatric CKD Patients with Ambulatory Hypertension: A Systematic Review and Meta-Analysis

Session Information

  • Pediatric Nephrology - I
    November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

  • 1900 Pediatric Nephrology


  • Chung, Jason, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada
  • Robinson, Cal, The Hospital for Sick Children, Toronto, Ontario, Canada
  • Yu, Andrew, University of Alberta, Edmonton, Alberta, Canada
  • Sheffield, Lauren, McMaster University, Hamilton, Ontario, Canada
  • Sinha, Manish, Evelina London Children's Hospital, London, London, United Kingdom
  • Dionne, Janis M., BC Children's Hospital, Vancouver, British Columbia, Canada
  • Mitsnefes, Mark, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
  • South, Andrew M., Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States
  • Parekh, Rulan S., Women's College Hospital, Toronto, Ontario, Canada
  • Rodrigues, Myanca D., McMaster University, Hamilton, Ontario, Canada
  • Noone, Damien Gerard, The Hospital for Sick Children, Toronto, Ontario, Canada
  • Chanchlani, Rahul, McMaster Children's Hospital, Hamilton, Ontario, Canada

The objective of this systematic review is to determine the association between ambulatory hypertension and left ventricular mass index (LVMI) as well as ambulatory blood pressure monitoring (ABPM) parameters in youth with CKD.


A systematic literature search on 9 databases included English publications from 1974-2022. LVMI was indexed to subject height and body surface area (g/m2.7). Correlation coefficients were transformed and pooled using a random effects model.


Of 1,128 screened studies, 16 studies and 2,254 children and adolescents were included. LVMI was elevated in the hypertensive group compared to the normotensive group (mean difference: 6.22 g/m2.7, 95% CI: 4.80-7.65). Hypertensive children were at 3.34 (95% CI: 2.38-4.68) increased odds of left ventricular hypertrophy compared to normotensive children. Estimates of pooled correlation coefficients demonstrated nighttime systolic (r=0.46, 95%CI: 0.36, 0.56) and daytime systolic (r=0.43, 95%CI: 0.33-0.53) BP to have the strongest positive linear relationship to LVMI.


Pediatric CKD patients with ambulatory hypertension especially during nighttime are at significant risk of increased LVMI. Adequate blood pressure control among children with CKD is imperative to avoid the risk of target organ damage and future cardiovascular disease.