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Abstract: TH-PO183

Correlation Between Serum suPAR and Severity of Renal Injury and Renal Function Progression in Diabetic Kidney Disease

Session Information

Category: Diabetic Kidney Disease

  • 702 Diabetic Kidney Disease: Clinical

Authors

  • Gu, Yue, Henan Provincial People's Hospital, Zhengzhou, Henan, China
  • Zhou, Jing, Henan Provincial People's Hospital, Zhengzhou, Henan, China
  • Ying, Ren Ying, Henan Provincial People's Hospital, Zhengzhou, Henan, China
  • Shao, Fengmin, Henan Provincial People's Hospital, Zhengzhou, Henan, China
Background

To analyze the correlation between serum soluble urokinase Plasminogen Activator Receptor (suPAR) and renal function in diabetic kidney disease(DKD).

Methods

152 DKD patients and 105 T2DM patients were recruited. The patients with DKD were divided into microalbuminuria group (30mg/g≤UACR < 300mg/g), macroalbuminuria group (UACR≥300mg/g). Spearman correlation and partial correlation analysis were conducted to compare the correlation between suPAR and various clinical indicators.End events were defined as Estimated glomerular filtration rate (eGFR) decrease of ≥30%, urinary protein advancement, progress to end-stage renal disease (ESRD) or receive renal replacement therapy. According to the median serum suPAR level, all patients were divided into low-level suPAR group (suPAR < 5.76ng/ml) and high-level suPAR group (suPAR≥5.76ng/ml). Survival curves were plotted by Kaplan-Meier method, and differences in renal cumulative survival at different serum suPAR levels were measured by Log-rank test. Cox regression analysis was used to analyze the influence factors for renal progression in DKD. The predictive value of suPAR in renal function progression was evaluated by Receiver operating characteristic curve (ROC).

Results

The mean age was 60.30±11.89 years old. SuPAR level in T2DM group was significantly lower than that in microalbuminuria group and macroalbuminuria group (P < 0.05).Serum suPAR in DKD patients was positively correlated with UACR, BUN, Scr, SUA, RBP and CysC (all P < 0.05), and negatively correlated with Hb, ALB, TBIL and eGFR (all P < 0.05). Kaplan-Meier survival analysis showed that the cumulative survival rate of kidney in the high-level suPAR group was significantly lower than that in the low-level suPAR group (P =0.001).The results showed that higher levels of RBP and suPAR, lower levels of ALB were independent risk factors for renal function progression in DKD patients (P < 0.05).The area under ROC curve of suPAR level to predict renal function progression was 0.791, the critical value was 8.15ng/ml, the sensitivity was 66.7%, and the specificity was 84.9%.

Conclusion

Serum suPAR level increased in DKD patients, which was positively correlated with the severity of renal impairment. High level of suPAR is an independent risk factor for renal progression in patients with DKD.

Funding

  • Government Support – Non-U.S.