Kidney Week

Abstract: TH-PO921

Different Effects of Dietary Selenium on All-Cause Mortality According to the Baseline Characteristics Based on the Nationwide Population Study: Results from the NHANES, 1999-2016

Session Information

• Health Maintenance, Nutrition, Metabolism - I
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1500 Health Maintenance, Nutrition, and Metabolism

Authors

• Kim, Yaerim, Keimyung University School of Medicine, Daegu, Daegu, Korea (the Republic of)

Yaerim Kim,

• Lee, Jeonghwan, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Dongjak-gu, Seoul, Korea (the Republic of)

Jeonghwan Lee,

• Jin, Kyubok, Keimyung University School of Medicine, Daegu, Daegu, Korea (the Republic of)

Kyubok Jin,

• Park, Woo Yeong, Keimyung University School of Medicine, Daegu, Daegu, Korea (the Republic of)

Woo Yeong Park,

• Kim, Dong Ki, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)

Dong Ki Kim,

• Lim, Chun Soo, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Dongjak-gu, Seoul, Korea (the Republic of)

Chun Soo Lim,

• Lee, Jung Pyo, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Dongjak-gu, Seoul, Korea (the Republic of)

Jung Pyo Lee,

Background

As an antioxidant, selenium has a beneficial role in human health including metabolism and thyroid function. Based on the metabolism process, kidney function status has a potential role in the bioavailability of dietary selenium. Herein, we aimed to evaluate the impact of dietary selenium on all-cause mortality in different baseline characteristics including kidney function status.

Methods

We used data from the US National Health and Nutrition Examination Survey 1999-2016. Based on a 1-day 24-hr dietary recall, the intake of selenium was divided by quintile; the third quintile was regarded as a reference. Baseline characteristics included kidney function, body mass index, and alcohol consumption status. We used a multivariate Cox proportional hazard model to identify the impact of selenium on all-cause mortality.

Results

A total of 41,423 subjects were included in the study. The risk for all-cause mortality was significantly increased in subjects included in the 1^st quintile (adjusted hazard ratio [aHR] 1.12, 95% confidence interval [CI] 1.03-1.21) after adjustment with age, gender, ethnicity, education, income, comorbidities (hypertension, diabetes), BMI, total calorie intake, laboratory results (hemoglobin, serum albumin, total cholesterol, serum glucose, and estimated glomerular filtration rate). In subgroup analysis, lower intake of selenium increased mortality in subjects with eGFR ≥60 mL/min/1.73 m2 (aHR 1.14, 95% CI 1.03-1.27), BMI 25-30 kg/m2 (aHR 1.24, 95% CI 1.08-1.43), and moderate to heavy drinker (aHR 1.27, 95% CI 1.11-1.44). Selenium intake and blood level of selenium showed a positive correlation, and it was prominent in subjects with eGFR <60, BMI 25-30, and non-drinkers. The impact of the blood level of selenium on all-cause mortality was the same as the results in selenium intake.

Conclusion

Deficiency in selenium intake and lower levels of blood selenium significantly increased all-cause mortality, especially in subjects with preserved kidney function, overweight, and moderate to heavy drinkers.