Abstract: SA-PO1076
Relationship of Serum Procalcitonin (PCT) Levels with Kidney Graft Function in the Immediate Post-transplantation Period in Kidney Transplant Recipients
Session Information
- Transplantation: Clinical - II
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Cerezo Samperio, Beatriz Rocío, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico
- Acosta Peña, Ana Cecilia, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico
- Compean, Abel Humberto Villanueva, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico
- López, Claudia Bethzabé, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico
- Morales Molina, Pedro, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico
- Nieto, Julio Cesar, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico
- Diaz Garcia, Juan Daniel, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico
- Ramirez, Irving Gaston, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico
- Cano Cervantes, Jose H., Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico
Background
Renal function is one of the major determinants of PCT levels, which is why its relationship as a marker of acute kidney injury not associated with sepsis has previously been described. In kidney transplantation (KT) the persistently high levels of PCT seem to show a relationship with the function of the kidney graft because its levels increase after the elevation of other inflammatory cytokines in events of exaggerated inflammatory response and it is poorly cleared in patients with delayed graft function. This study seeks to find the relationship of serum PCT levels as well as their association with kidney graft function in the immediate period.
Methods
We conducted a retrospective cohort study from February 2016 to May 2022 of Nephrology and Transplant patients. A number of 82 KT recipient patients with PCT determination in the immediate postransplant period were obtained. Statistical analysis: Descriptive statistics, interferential statistics were performed by comparing groups and intragroup for categorical variables with x2 and Fisher's exact test; for non-parametric continuous variables Mann-Whitney U.
Results
They were classified as normal graft function (NGF), slow graft function (SGF) and delayed graft function (DGF). Within the baseline characteristics, no statistically significant differences were found for age, type of transplant, leukocytes, and hemoglobin at admission. Finding that a level > 3 ng/dl of procalcitonin conferred a greater risk of DGF, as well as higher levels in this group compared to patients with NGF.
Conclusion
Procalcitonin is an early marker to identify patients who develop delayed kidney graft function.
Characteristics
| Variable | NGF n = 23 | DGF n = 45 | SGF n = 14 | P value |
| Age (years) | 37 ± 12 | 43 ± 15 | 46 ± 16 | 0.155 |
| Male (%) | 10 (43) | 26 | 13 | 0.310 |
| Deceased Donor (%) | 16 | 35 | 12 | 0.556 |
| Cold ischemia (Hrs) | 11.5 (1-14.25) | 16 (12-18) | 13.25 (10.25-15.25) | 0.0145 |
| Leukocytes (miles/mm3) | 7.5 (5.5-8.6) | 7.9 (5.8-12.3) | 8.6 (4.7-13.1) | 0.562 |
| Procalcitonin (ng/ml) | 1.41 (0.23 – 3.97) | 5.6 (0.79 – 29) | 2.55 (0.37 – 6.77) | 0.0230 |
| PCT > 3 ng/dL | 6 | 26 | 4 | 0.0203 |
NGF: Normal Graft Function; DGF: Delayed Graft Function; SGF: Slow Graft Function; Hrs: Hours; Min: Minutes.