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Abstract: SA-PO447

Association of FRMD3 and ACE Gene Polymorphisms with Diabetic Nephropathy and Non-Diabetic Kidney Disease

Session Information

Category: Diabetic Kidney Disease

  • 701 Diabetic Kidney Disease: Basic

Authors

  • Diaz Garcia, Juan Daniel, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico
  • Morales Lopez, Enrique Fleuvier, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico
  • Alamilla-Sanchez, Mario, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico
  • Lara Palafox, Oscar, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico
  • Muñoz Arellano, Juan Ernesto, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico
  • Ortega, Jose Luis, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico
Background

FRMD3 and ACE gene polymorphisms have been suggested as an alternative test to differentiate diabetic nephropathy from non-diabetic kidney disease in patients with type 2 diabetes mellitus. This study was conducted to investigate the relationship between FRMD3 and EA genes. and the clinical features of diabetic nephropathy.
Objective: To determine the association of FRMD3 and ACE gene polymorphisms with diabetic nephropathy and non-diabetic kidney disease.

Methods

Patients who already had renal pathology findings were evaluated for ACE and FRMD3 polymorphisms. The subjects were classified into three groups; diabetic nephropathy, diabetic patients with other non-diabetic nephropathy and healthy patients. Polymorphisms of the ACE and FRMD3 genes were analyzed in each group.

Results

In a total of 200 patients from a reference medical center, the prevalence of GG, CG and CC was 45%, 43% and 12% respectively. There were no significant differences in clinical parameters, which consisted of disease duration, proteinuria, and complications in diabetic patients. The G allele was found mainly in patients with diabetic nephropathy (50.5%) while the C allele was found in patients with diabetes and other types of nephropathy (43.9%) (p = 0.02). There was a significant association between the CC genotype in patients with diabetes and other types of kidney disease compared to GG (p = 0.001). In addition, the C allele was 2.2 times more associated with diabetes and other kidney disease than the G allele (p = 0.03). The CC genotype was correlated with the risk of diabetes and other kidney disease than the GG and GC genotypes, with odds ratios of 6.6 and 4.5, respectively (p = 0.02).

Conclusion

Regarding the FRMD3 and ACE genes evaluated, the presentation of the C allele, especially homozygous CC, was associated with patients with diabetes and other types of nephropathy in patients with overt proteinuria. Therefore, renal biopsy is suggested in those with the C allele or the homozygous CC genotype.