Abstract: SA-PO096
Renal Function Recovery After Urinary Stone Removal Is Diverse for Patients with Urinary Stones in Different Locations
Session Information
- AKI: Epidemiology, Risk Factors, Prevention - II
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Author
- Wen, Wen, Beijing Tsinghua Changgung Hospital, Beijing, Beijing, China
Background
The impact on renal function might be diverse in urolithiasis in different locations. We conducted a retrospective cohort study to analyze the trend of estimated glomerular filtration rate (eGFR) variation for urolithiasis in different locations after stone removal.
Methods
Clinical and laboratory characteristics of urolithiasis patients hospitalized in Beijing Tsinghua Changgung Hospital from March 2015 to September 2017 were screened according to our eligibility criteria. Creatinine values on 4 different time points (before surgery, 1 day after surgery, 7 days after surgery, and 1 month after surgery) were collected. Multi-level random effect models were constructed and the variations of eGFR were compared among patients with different stone locations. Subgroup analyses were done in patients with impaired renal function at baseline (eGFR < 60ml/min*1.73m2).
Results
Among the 760 urolithiasis patients included (mean age: 50.8 ± 21.6 years, males: 62.8%), 483 had kidney stones, 168 were with ureter stones, and 109 had stones in both kidney and ureter. Coronary artery disease, urinary tract infection, hemoglobin, and serum albumin were unevenly distributed factors (P<0.001). The greatest improvement in eGFR and the most significant proportion of eGFR improvement was seen in patients with ureter stones. In contrast, the worst eGFR recovery was noted in patients with kidney stones (P<0.001). In multi-level models adjusted for related factors or not, a decrease of eGFR was noted at day 7 and an increase of it was observed at day 30 compared to baseline (P<0.05). Similar trends were noted in patients with ureter stones and those with kidney&ureter stones. However, the eGFRs kidney stone patients were not improved at day 30 (P>0.05).
Conclusion
Patients with stones only located in kidney may have the worst outcome in renal recovery after surgery. Large prospective studies are warranted to further establish the relationship between stone location and renal recovery.
eGFR variations in patients with different stone locations
Funding
- Private Foundation Support