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Abstract: SA-PO137

The Impacts of Skeletal Muscle Mass and Quality on Kidney Recovery of Patients with AKI Receiving Continuous Renal Replacement Therapy

Session Information

Category: Acute Kidney Injury

  • 102 AKI: Clinical, Outcomes, and Trials

Authors

  • Park, Jae Yoon, Dongguk University Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
  • Paek, Jin hyuk, Keimyung University Dongsan Medical Center, Daegu, Korea (the Republic of)
  • Jung, Jiyun, Dongguk University Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
  • Lim, Jeong-Hoon, Kyungpook National University Hospital, Daegu, Korea (the Republic of)
  • Kim, Yong Chul, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
  • Ban, Tae Hyun, The Catholic University of Korea School of Medicine, Seoul, Korea (the Republic of)
  • Kim, Kipyo, Inha University School of Medicine, Incheon, Korea (the Republic of)
  • Kim, Hyosang, Asan Medical Center, Songpa-gu, Seoul, Korea (the Republic of)
  • Park, Woo Yeong, Keimyung University Dongsan Medical Center, Daegu, Korea (the Republic of)
Background

Although there are increasing interests in kidney recovery after acute kidney injury (AKI), little is known about patients with severe AKI requiring continuous renal replacement therapy (CRRT). It is known that sarcopenia is associated with poor prognosis not only in chronic inflammatory conditions but also in acute disease. Recent study revealed that muscle mass and quality were significant determinants of mortality in patients with CRRT. However, few studies evaluated the effect of sarcopenia on kidney recovery in patients receiving CRRT.

Methods

We collected 2051 AKI patients who underwent CRRT from eight medical centers between 2006 and 2021. The skeletal muscle area (SMA) was measured from the automated software from CT images at 3rd lumbar vertebra within 15 days of CRRT initiation, and classified as normal attenuation muscle area (NAMA) and low attenuation muscle area (LAMA) according to muscle density. We used Fine and Gray model to investigate the effects of muscle index adjusted by body mass index (BMI) on kidney recovery.

Results

Of the 813 CRRT survivors, 682 (83.9%) patients were discharged without RRT. Increased SMA/BMI was independently associated with decreased risk of RRT dependence. Also, the 4th quartile of NAMA/BMI was significantly associated with decreased RRT dependence risk. However, non-significant effects of LAMA/BMI were observed.

Conclusion

In patients with severe AKI receiving CRRT, not only the quantity but also the quality of muscle affects RRT dependence.