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Abstract: TH-PO1017

Particulate Matter and Risk of CKD: A Global Exposure-Response Analysis

Session Information

Category: CKD (Non-Dialysis)

  • 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention


  • Zhang, Feifei, Peking University Health Science Center, Beijing, Beijing, China

Associations between particulate matter (PM) air pollution and chronic kidney disease (CKD) have been increasingly reported, yet the exposure-response association is insufficiently estimated. This study aimed to combine all available associations between PM of two different sizes (PM2.5 and PM10) and CKD to generate exposure-response functions over concentrations experienced by populations in the globe.


Based on data from two prospective, population-based cohorts in the United Kingdom and China (UK biobank and China Health and Retirement Longitudinal Study), we used the shape constrained health impact function to generate exposure-response functions between both PM2.5 and PM10 and CKD within each country. We then collected additional data on PM2.5-CKD and PM10-CKD associations from published literature and used the global exposure mortality model to construct exposure-response functions for CKD over a full range of global PM2.5 and PM10 concentrations.


In the United Kingdom, the exposure-response functions for both PM2.5 and PM10 and CKD showed a linear association at lower concentrations and then a sublinear association at higher concentrations. In China, the risk of CKD also increased linearly with the increasing PM2.5 and PM10 at lower concentrations, but the associations for both air pollutants did not reach the statistical significance. After combining with all other published associations, the exposure-response function revealed a near linear association of the natural log relative risk of CKD with PM2.5 (Figure 1a) and a sublinear association with PM10 (Figure 1b), respectively.


Both PM2.5 and PM10 exposure increased the risk of CKD, particularly at higher concentrations. Our findings highlight the urgency for air pollution management in areas with severe PM pollution to protect kidney health.

Figure 1 Exposure-response relationships between particulate matter and chronic kidney disease. (a) PM2.5, (b)PM10. Red line represents the log (relative risk) and grey shaded area represents its 95% confidence intervals.