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Abstract: FR-PO905

White Matter Alternation at Corpus Callosum and Stria Terminalis Contributes to the Cognitive Impairment in ESRD via Dysregulating Homeostasis of Calcium

Session Information

  • Geriatric Nephrology
    November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Geriatric Nephrology

  • 1300 Geriatric Nephrology

Author

  • Hou, Yi-Chou, Cardinal Tien Hospital, New Taipei City, Taiwan
Background

Cognitive impairment is common in patients with end stage kidney disease (ESRD). White matter alternation is important pathologic change in cognitive impairment, and fixel-based analysis quantifies the fiber loss. The study is to elucidate the white matter alternation in uremic cognitive impairment patients .

Methods

The study period was from August 2019 to December2020. The participants were divided into three groups according to the MMSE score and the status with end stage renal disease or not: (1) control (n=16): MMSE>24 without end stage renal disease; (2)group2 (n=17): end stage renal disease with MMSE 25~30; (3) group 3 (n=14): end stage renal disease with MMSE10~24. All participants received magnetic resonance imaging and hematologic and biochemical parameters. Fixel-based analysis was performed to assess the fiber density.

Results

The fiber density, the fiber cross section and the summation of the fiber density and cross section were lower in the ESRD patients. The decrease in corpus callosum and fornix/stria terminalis was associated with the decrease in Montreal Cognitive Assessment(p<0.05). The concentration of calcium(8.80± 0.79mg, vs 9.27± 0.29mg for control group, p<0.05) was lower in ESRD patients. The serum concentration of calcium was positive associated with the fiber density in the corpus callosum and fornix/stria terminalis(p<0.05).

Conclusion

The white mater density decreased in the ESRD patients, and the decrease was associated with cognitive impairment. Serum calcium positively correlated with the fiber density in corpus callosum and fornix terminalis.

The association between imparied fibers and MoCA.

The fibers influenced by calcium concentration.