Abstract: FR-PO1105
COVID-19 Vaccine Immune Response in Hemodialysis Patients
Session Information
- COVID-19 - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Coronavirus (COVID-19)
- 000 Coronavirus (COVID-19)
Authors
- Gulzar, Kashif, Dubai Health Authority, Dubai, Dubai, United Arab Emirates
- Alalawi, Fakhriya Juma Abdulla, Dubai Health Authority, Dubai, Dubai, United Arab Emirates
- Alnour, Hind Hassan, Dubai Health Authority, Dubai, Dubai, United Arab Emirates
- Al Hadari, Amna Khalifa, Dubai Health Authority, Dubai, Dubai, United Arab Emirates
Background
COVID-19 infection is associated with increased morbidity and mortality in chronic kidney disease patients, especially those on maintenance hemodialysis. The comparison of immunogenicity of different COVID vaccines in the dialysis populations is lacking especially in the middle east region.
Methods
We conducted a retrospective observational study, that includes 164 hemodialysis patients (HD) and 54 health workers (HW), who received 2 doses of either Pfizer-BioNTech or Sinopharm vaccine. The primary endpoint was to report the rate of seroconversion and the factors affecting it.
Results
HD patients have a significantly low seroconversion rate than HW (HD vs HW: 76.54% and 100%, p=<0.05), also S1 IgG antibody level was significantly low in HD patients (HD vs HW: 183.5 and 400 BAU/ml, p=<0.05). The type of vaccine and hypo-response to the HBV vaccine were two statistically significant factors affecting the seropositivity rate in HD patients. As compared to Sinopharm, Pfizer-BioNTech vaccinated HD patients exhibit not only higher seroconversion rate (Pfizer-BioNTech vs Sinopharm: 90.80% and 60%, p=<0.05) but also express high S1 antibody titer (Pfizer-BioNTech vs Sinopharm: 425 and 162 BAU/ml (p=<0.05), however, there is no significant difference in post-vaccine COVID infection rate among the two vaccines (Pfizer-BioNTech vs Sinopharm: 39.24% and 42.22% (p= 0.176).
Conclusion
Lower Immune response to the COVID vaccine is observed in HD patients as compared to HW participants, also Pfizer-BioNTech vaccinated HD patients exhibit better seroconversion rates and higher antibody titer than Sinopharm vaccine in HD patients, so alternative vaccine strategies should be designed in dialysis patients