ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

Abstract: SA-PO669

Optical System Shows Promise for Online Detection of Peritonitis in Peritoneal Dialysis

Session Information

  • Home Dialysis - II
    November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

  • 802 Dialysis: Home Dialysis and Peritoneal Dialysis

Authors

  • Kushnir, Daniel, Carmel Medical Center, Haifa, Haifa, Israel
  • Tanasiychuk, Tatiana, Carmel Medical Center, Haifa, Haifa, Israel
  • Perl, Jeffrey, St. Michael’s Hospital, Toronto, Ontario, Canada
  • Teitelbaum, Isaac, University of Colorado, Denver, Colorado, United States
  • Tsoory, Hezkiah, liberDi Ltd, Or Akiva, Israel
  • Zacharin, Dimitry, liberDi Ltd, Or Akiva, Israel
  • Dayan, Ron, liberDi Ltd, Or Akiva, Israel
  • Frajewicki, Victor, Carmel Medical Center, Haifa, Haifa, Israel
Background

Peritoneal Dialysis (PD) is associated with significant patient morbidity and mortality. Prompt peritonitis diagnosis and treatment is crucial and may be limited by the lack of early patient or care partner recognition of peritonitis signs and symptoms thereby delaying clinical presentation and treatment and adversely impacting peritonitis treatment outcomes.

Methods

The Intelligent Dialysis Assistant (IDA), a new electronic automated ambulatory PD exchange device (part of liberDi's Digital Dialysis Clinic) provides aseptic PD exchanges. The IDA is fitted with an inline WBC sensor that can transmit online detection of white blood cells (WBC) in the PD effluent and aid in the early diagnosis of peritonitis. To check the capabilities of the sensor in- vitro, we created PD solutions with a range of 150- 16,000 cells/μL to mimic PD effluent peritonitis conditions.

Results

The sensor installed in the IDA (part of liberDi’s Digital Dialysis Clinic) was able to detect the different concentrations of white blood cells in the solution (from 150 through 16,000 cell/μL), with a high linear correlation (R2 =0.98).

Conclusion

A point-of-care testing system for detecting peritonitis using a sensor is a promising approach that may improve the prompt diagnosis and treatment of peritonitis in PD patients. The ability of the installed sensor in the IDA to detect low concentrations and volumes of white blood cells suggests that may be a reliable tool to detect peritonitis in the PD effluent and will require validation via further clinical studies.

Figure 1 illustrates how the differences in optical system readings between the infected solution and the reference solution varies with different concentrations of white blood cells for two tested blood samples, as well as the average of those samples. Each point denotes 103 readings.

Funding

  • Commercial Support – liberDi