Abstract: FR-PO844
Multiple Pregnancy Can Induce Preeclampsia-Like Changes in Complement Factor H Point Mutation Mice
Session Information
- Women's Health and Kidney Diseases
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Women's Health and Kidney Diseases
- 2200 Women's Health and Kidney Diseases
Authors
- Chen, Feifei, Peking University First Hospital, Beijing, Beijing, China
- Tan, Ying, Peking University First Hospital, Beijing, Beijing, China
Background
Preeclampsia is a severe placenta-related pregnancy disorder, its pathogenesis has still not been fully elucidated. Studies suggested a link between complement activation and preeclampsia. In view of that normal pregnancy can induce appropriate activation of the complement system, we assumed that patients with preeclampsia may have increasing genetic susceptibility to overactivation of complement system, and under the burden of pregnancy, overactivation of the complement system occurs, in turn leading to the occurrence of preeclampsia.
Methods
We mated the female and male mice with heterozygous mutations in complement factor H through five times and assessed clinicopathological indicators of preeclampsia.
Results
Along with complement activation, multiple pregnant heterozygous complement H mutation mice recapitulated the key features of human preeclampsia: hypertension, proteinuria, elevated blood urea nitrogen, lactic dehydrogenase, reduced placental weight, restricted fetal growth, typical histology change in placenta and kidney of preeclampsia, placental imbalance of angiogenesis and renal endothelial cell injury.
Conclusion
This study provided direct evidence that pregnant status can induce overactivation of complement system in mice with mutation in complement regulator gene, which could lead to the development of preeclampsia. This model provided a new option for the investigation of the pathogenesis of preeclampsia.