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Kidney Week

Abstract: SA-PO165

Acute Exposure to Particulate Matter Affects Renin-Angiotensin System in the Kidneys

Session Information

  • AKI: Mechanisms - III
    November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Acute Kidney Injury

  • 103 AKI: Mechanisms

Authors

  • Cha, Jin Joo, Korea University Ansan Hospital, Ansan, Korea (the Republic of)
  • Tae, Bum Sik, Korea University Ansan Hospital, Ansan, Korea (the Republic of)
Background

Recent studies have shown that exposure to fine particulate matter (PM) leads to systemic inflammation and furthermore increases the risk of cardiovascular disease. Epidemiologic studies have shown a significant association between exposure to PM and chronic kidney disease and progression to end-stage renal disease. In order to understand the underlying mechanism of PM to systemic effects, we examined the effects of acute exposure to high-concentration fine PM on kidney injury in an experimental mice model.

Methods

Unilateral Ureteral Obstruction (UUO) was induced in 10-week-old Sprague Dawley rats. For fine PM, we used Carbon black CP(CAS No 1333-86-4) dispersed in a specialized inhalation chamber. SD rats were exposed to high-concentration CP particles for 3 hours for 3 days in a nose-only inhalation chamber. Groups were divided into 1) Control, 2) UUO, 3) PM, 4) UUO + PM, 5) UUO+ PM+ ARB L158809 (Merck & Co, Inc, NJ, USA) by drinking water (1.5mg/kg/d).

Results

Weight loss was apparent in rats exposed to carbon black and PM exposure groups. Blood pressure was significantly elevated after the study in the PM and UUO groups. In the lung of PM exposure, renin, angiotensinogen, AT2R gene expression significantly increased and ACE2 decreased. In the kidney, the expressions of renin, and angiotensinogen were not changed after PM exposure, but ACE2 expression significantly decreased in the kidney and UUO further diminished the expression. ARB treatment restored the expression.

Conclusion

Altogether, these findings suggest that exposure to PM can affect the renin-angiotensin system in the kidney, in a different manner from other organs.