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Abstract: TH-PO188

Association of Urinary DNlite IVD-103 with CKD and Coronary Artery Disease in Diabetic Nephropathy

Session Information

Category: Diabetic Kidney Disease

  • 702 Diabetic Kidney Disease: Clinical

Authors

  • Bandi, Varun Kumar, Dr Pinnamaneni Siddhartha Institute of Medical Sciences & Research Foundation, Vijayawada, Andhra Pradesh, India
  • Nnss, Harsha, Dr Pinnamaneni Siddhartha Institute of Medical Sciences & Research Foundation, Vijayawada, Andhra Pradesh, India
  • Chaganti, Sindhu, Dr Pinnamaneni Siddhartha Institute of Medical Sciences & Research Foundation, Vijayawada, Andhra Pradesh, India
Background

Fetuin-A is associated with inflammation and vascular complications in diabetes. We evaluated association of urinary post-translationally modified fetuin-A (DNlite IVD-103) in diabetics with chronic kidney disease (CKD) and coronary artery disease (CAD).

Methods

A cross-sectional study was conducted in patients with diabetic nephropathy. Patients and divided into those having only albuminuria, CKD or CAD. eGFR (Glomerular Filtration Rate) was calculated using CKD-EPI equation, and an eGFR <60ml/min/1.73m2 was considered CKD. Severity of CAD was assessed using SYNTAX score. Spot urine was tested for urine albumin to creatinine ratio (UACR), and DNlite-IVD103 (Fetuin) was measured using ELISA test kit. Urinary Fetuin:creatinine ratio (UFCR) was calculated. Statistical analysis was carried out using SPSS v23.0. A p value of <0.05 was considered significant.

Results

137 patients were included, with 61% being men. The mean age, eGFR, UACR, and FCR were 56.4±11.8 years, 64.5±36.4 ml/min/1.73m2, 1359±2030.6 mg/g, and 175±268.9 ng/g, respectively. Of these, 20.4% of patients had CAD, 39.4% had albuminuria, and 40.1% had CKD. There was a significant difference in UACR and UFCR between the groups. UACR had significant positive correlation with age and negative correlation with eGFR (p<0.05). UFCR had significant negative correlation with eGFR. UFCR was also significantly higher in patients with CKD compared to CAD (p<0.05). Compared to albuminuria patients, UACR, and UFCR were significantly increased in patients with CAD (p<0.05) and CKD (p<0.01). In patients with CAD, SYNTAX II score had significant negative correlation with UFCR (p<0.05) but not UACR (p=0.58)

Conclusion

DNlite IVD-103 is significantly associated with worsening renal function, and is not influenced by age. It was also significantly different between CAD & CKD, and also had significant correlation with severity of CAD. UFCR could be used to stratify patients with micro- or macrovascular disease (albuminuria, CAD, CKD).

Funding

  • Commercial Support – Bio Preventive Medicine Corp, Taiwan