Abstract: FR-OR92
Association of Polygenic Risk Scores for Blood Pressure with Incidence of Hypertension and CKD
Session Information
- Novel Clinical Impacts on Cardiorenal Disease
November 03, 2023 | Location: Room 103, Pennsylvania Convention Center
Abstract Time: 04:39 PM - 04:48 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Kim, Soyeon, Soonchunhyang University Hospital, Seoul, Korea (the Republic of)
- Kwon, Soon hyo, Soonchunhyang University Hospital, Seoul, Korea (the Republic of)
- Noh, Hyunjin, Soonchunhyang University Hospital, Seoul, Korea (the Republic of)
- Kim, Hyoungnae, Soonchunhyang University Hospital, Seoul, Korea (the Republic of)
- Lee, Haekyung, Soonchunhyang University Hospital, Seoul, Korea (the Republic of)
Background
Genetic risk for elevated blood pressure (BP) has been associated with a higher risk of hypertension and cardiovascular disease. However, the generalizability of previous findings has been limited due to a lack of studies among Asian populations. This study aimed to investigate whether genetic risk for BP predicts the incidence of hypertension and chronic kidney disease (CKD).
Methods
We constructed polygenic risk scores (PRSs) for systolic and diastolic BP (SBP and DBP, respectively) using genome-wide association data from the Biobank Japan. We then examined the association between BP PRSs and incident hypertension or CKD in the Korean Genome and Epidemiology Stduy. The study included participants without hypertension, cardiovascular disease, or CKD at baseline (n = 4351, median age 48 years, 48.8% men). Participants were categorized into four groups based on their PRS percentile (<5%, 5-50%, 50-95%, >95%).
Results
The PRS for SBP and DBP showed independent associations with SBP and DBP, respectively (both P <0.001). Compared to individuals with the lowest 5% SBP PRS, those with SBP PRS in the 50 to 95 percentile range and the highest 5% had a 1.62-fold (95% confidence interval [CI], 1.24–2.11; P <0.001) and 1.75-fold (95% CI, 1.23–2.49, P = 0.002) higher risk of hypertension, respectively. Elevated DBP PRS was associated with 1.47-fold (95% CI, 1.11–1.94, P = 0.006), 1.79-fold (95% CI, 1.35–2.35, P <0.001), and 2.03-fold (95% CI, 1.41–2.91, P <0.001) higher risk of hypertension in the 5 to 50 percentile, 50 to 95 percentile, and the highest 5%, respectively. The highest PRS percentile for SBP and DBP was associated with earlier onsets of hypertension by 5.9 years (95% CI, 2.9–8.9) and 6.7 years (95% CI, 3.9–9.4), respectively, compared to the lowest PRS percentile for SBP and DBP. However, both SBP and DBP RPSs were not associated with incident CKD.
Conclusion
Genetic risk for elevated BP was associated with a higher risk of incident hypertension and earlier onset of hypertension in the general population. However, there was no association between PRS for elevated BP and the incidence of CKD.