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Abstract: SA-PO583

Correlation of Cardiac Function by Transthoracic Ultrasound and State of Inflammation in Asymptomatic Young Patients (18-40 Years), with Hemodialysis: A Single-Center Experience

Session Information

Category: Dialysis

  • 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Arizpe, Lizeth, Universidad de las Americas Puebla, Cholula, Puebla, Mexico
  • Rodney, Marianela, Instituto Cardiorenal de Puebla, Puebla, Puebla, Mexico
  • Baez, Elizabeth, Universidad de las Americas Puebla, Cholula, Puebla, Mexico
  • Castillo García, Armando, Universidad de las Americas Puebla, Cholula, Puebla, Mexico
  • Jimenez Hernandez, Mario, Universidad de las Americas Puebla, Cholula, Puebla, Mexico
Background

Cardiac pathology is currently one of the leading causes of mortality worldwide, with chronic kidney disease being a major risk factor for cardiovascular-related deaths, especially in patients undergoing renal replacement therapy. Patients undergoing renal replacement therapy,
such as hemodialysis, are subject to frequent changes in volume and persistent systemic inflammation. However, early monitoring and management of heart failure in young patients with chronic kidney disease are often lacking.

Methods

The aim of this observational, descriptive, and cross-sectional study was to evaluate the degree of cardiac dysfunction and inflammatory profile in young, asymptomatic hemodialysis patients, by analyzing their medical records, clinical analysis to evaluate the inflammatory profile of hemodialysis patients and performing a transthoracic echocardiogram.

Results

The study included 24 hemodialysis patients with a median age of 29 years (range 24-38 years) and no history of systemic arterial hypertension or cardiac disease at the time of data collection. There was a direct correlation between anemia and systolic dysfunction (p=0.013), as well as anemia and diastolic dysfunction (p=0.043). In relation with inflammatory profile we founded that elevated levels of ferritin were correlated with a higher degree of diastolic dysfunction (p=0.023), and low ferritin levels were associated with pericardial effusion (p=0.043).

Conclusion

Asymptomatic young patients on hemodialysis present with subclinical cardiac dysfunction associated with metabolic and inflammatory disorders. The presence of pericardial effusion was not associated with elevated inflammatory parameters, therefore detection of pericardial effusion by echocardiography is necessary for adequate control and preservation of cardiac function.