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Abstract: SA-PO1002

Preliminary Renal Biopsy Registry: Dominican Republic

Session Information

Category: Glomerular Diseases

  • 1403 Podocyte Biology

Authors

  • Gutierrez, Anthony Jose, Pontificia Universidad Catolica Madre y Maestra, Santiago de los Caballeros, Dominican Republic
  • Cruz, Juan Manuel, Pontificia Universidad Catolica Madre y Maestra, Santiago de los Caballeros, Dominican Republic
  • Atizol Rodriguez, Denazir, Pontificia Universidad Catolica Madre y Maestra, Santiago de los Caballeros, Dominican Republic
  • Batista, Jordy, Pontificia Universidad Catolica Madre y Maestra, Santiago de los Caballeros, Dominican Republic
  • Checo, Rocio E., Pontificia Universidad Catolica Madre y Maestra, Santiago de los Caballeros, Dominican Republic
  • Dina-Batlle, Eliana, Hospital Metropolitano de Santiago, Santiago De Los Caballeros, Dominican Republic

Group or Team Name

  • Grupo colaborativo Registro Nacional Biopsia Renal RD.
Background

The rising incidence of renal diseases and the need to enhance their prevention, diagnosis, and treatment have prompted the establishment of national renal biopsy registries. These registries provide essential information about the epidemiology of renal diseases and can inform the design of clinical trials and the development of therapeutic strategies. With this premise, the Preliminary Renal Biopsy Registry was implemented in the Dominican Republic, aiming to compile and analyze renal biopsy data nationwide. This registry provides a valuable data source for studying renal diseases in this specific country, enabling the identification of risk factors and the evaluation of the effectiveness of public health interventions.

Methods

A retrospective database analysis was conducted, collecting national renal biopsy data. A call was made to nephrologists performing renal biopsies through the national society. Biopsies from 2002 to 2022 were included.

Results

A total of 929 biopsy were included of this study. Consisting of 814 (87.62%) non-transplanted and 115 (12.38%) transplanted patients. 455 (55.9%) were female, 604 (74.2%) biopsies were performed in northern part of the country and just 32 patients (3.9%) were re-biopsied. The five more common primary biopsy diagnosis in non-transplanted patient were the following: focal segmental glomerulosclerosis 174 (21.4%), lupus nephritis (14.3%), minimal change disease (10.3%), membranous nephropathy 73 (9%) and Alport syndrome/thin membrane disease 66 (8.1%). In transplanted patients however, the five more common were: acute rejection 45 (39.1%), no rejection 25 (21.7%), chronic rejection 22 (19.1%), acute tubular necrosis 5 (4.3%) and focal segmental glomerulosclerosis 4 (3.5%).

Conclusion

According to our study, FSGS was the most common type of glomerulonephritis in our population. Also, this study showed a high frequency of Lupic nephritis, ranking second among all the glomerulonephritis diagnoses, followed by minimal change disease. This pattern is similar to other studies in Latin America, revealing a higher frequency of lupus nephritis compared to European and American countries. This information is essential to realize and emphasize kidney diseases' importance, especially autoimmune glomerular disorders in Latin America.