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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Abstract: INFO11-SA

Indiana Center for Advanced Renal Microscopy and Molecular Imaging

Session Information

  • Informational Posters - III
    November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Educational Research

  • No subcategory defined

Authors

  • Dunn, Ken, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Eadon, Michael T., Indiana University School of Medicine, Indianapolis, Indiana, United States
  • El-Achkar, Tarek M., Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Sutton, Timothy A., Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Winfree, Seth, University of Nebraska Medical Center, Omaha, Nebraska, United States
  • Liu, Jonathan T. C., University of Washington, Seattle, Washington, United States
  • Dagher, Pierre C., Indiana University School of Medicine, Indianapolis, Indiana, United States
Description

The Indiana Center for Advanced Renal Microscopy and Molecular Imaging provides unique imaging services to the renal research community and serves as a national resource for investigators applying advanced imaging techniques to research in kidney biology. The services offered by the Indiana O’Brien Center include 1) quantitative intravital microcopy of mice and rats as well as hands-on training to encourage dissemination of intravital microscopy as an effective research tool, 2) quantitative, large-scale microscopy of the kidney including three-dimensional confocal tissue cytometry, CODEX multiplexed cytometry, and spatial transcriptomics as individual services or in combination to help support uniquely comprehensive molecular characterizations, and 3) development and implementation of methods of tissue clearing, open-top light-sheet (OTLS) microscopy and digital image analysis to expand the scale of quantitative microscopy of kidney tissues. The unique combination of multiscale/ multi-resolution imaging strategies and state-of-the-art methods of digital image analysis will help kidney investigators realize the potential of quantitative microscopy as a tool in kidney research. The Indiana O’Brien Center offers a Pilot and Feasibility Program that provides funding and technical support for pilot projects for early-stage investigators and to attract new researchers into the field of kidney biology. The Indiana O’Brien Center also offers bi-annual imaging workshops that serve to disseminate technical developments of the Center, attract outside investigators into kidney research and inform renal researchers of emerging advances in imaging science that are applicable to kidney research.

Funding

  • National Institute of Health- NIDDK