ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

Abstract: INFO08-TH

Mayo Clinic Polycystic Kidney Disease Center

Session Information

  • Informational Posters - I
    November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidneys

  • No subcategory defined

Authors

  • Sussman, Caroline R., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Yang, Hana, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Gregory, Adriana, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Li, Xiaoyan, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Mann, Zoey, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Sieben, Cynthia J., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Schauer, Rachel S., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Kennedy, Kristian M., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Huang, Yan, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Romero, Michael F., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Dahl, Neera K., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Hanna, Christian, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Irazabal, Maria V., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Li, Xiaogang, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Hu, Jinghua, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Kline, Timothy L., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Torres, Vicente E., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Harris, Peter C., Mayo Clinic Minnesota, Rochester, Minnesota, United States
Description

The Mayo Clinic PKD Center consists of a team of expert faculty working in basic research and comprehensive adult and pediatric PKD clinics. We aim to conduct and support studies from fundamental discovery, through translational analyses in model systems and human subjects, to performing clinical trials. We actively share materials, resources, and expertise to support both academic and industry sponsored PKD research. Our primary objective is to facilitate breakthroughs in basic research and apply these in the PKD clinic.
The Center has three main areas of focus: Genetics, Epigenetics, and Metabolomics (GEM), Model Systems, and Imaging. The GEM core specializes in genetic profiling of PKD patients to understand etiology and discover potential therapies and biomarkers. We also maintain a Cystic Kidney and Liver Disease Biobank where PKD patient materials are collected and shared. We also manage the PKD Foundation ADPKD Mutation Database, which evaluates the significance of variants in the PKD1 and PKD2 genes.
The Model Systems core develops and maintains C. elegans, zebrafish, rodent, and pig PKD systems that are available for collaboration or sharing. Additionally, we have standardized protocols for zebrafish and murine preclinical testing to evaluate the efficacy of novel therapeutics. For higher throughput and cost-effective drug screening, we offer orthologous C. elegans and zebrafish models.
The Imaging core is continuously advancing protocols for both preclinical and clinical imaging, including 3D ultrasound, CT, and quantitative MR utilizing cutting-edge image processing techniques such as radiomics, machine learning, and deep learning analysis. Standardized protocols are available to accurately and automatically analyze organ volume, cyst number, and size, providing enhanced patient-specific image-based metrics.
We actively support aspiring researchers at various levels, ranging from undergraduate students to junior faculty members. This includes offering Summer Undergraduate Research Fellowships through an R25 grant and Postdoctoral Fellowships.