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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Abstract: INFO13-FR

Pittsburgh Center for Kidney Research: A George M. O'Brien Kidney National Resource Center

Session Information

  • Informational Posters - II
    November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Fluid, Electrolytes, and Acid-Base Disorders

  • No subcategory defined

Authors

  • Kleyman, Thomas R., University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Weisz, Ora A., University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Description

The Pittsburgh Center for Kidney Research is supported by a George M. O’Brien Kidney National Resource Center grant from NIDDK, by the University of Pittsburgh, UPMC and the Ichan School of Medicine at Mount Sinai. The main goal of our Center is to provide investigators across the US with expertise in both classical and novel physiological approaches to dissect kidney function in normal and disease states. Our Cores provide an integrated approach to address kidney-specific questions across a broad range of physical resolutions, ranging from molecules to whole animals using a variety of model systems amenable to genetic manipulation, and complement these studies using cutting edge imaging approaches tailored for an investigator’s specific needs. Our Physiology Core is a resource for investigators who wish to study ion transporters and associated regulatory proteins using isolated tubules of defined identity, primary cell isolates, established cell lines, induced pluripotent stem (iPS) cell-derived kidney organoids or heterologous expression systems. Our Model Systems Core serves is a resource for investigators to employ a host of model systems to address specific questions regarding kidney physiology, cell biology and pathophysiology, including yeast, proximal tubule and distal nephron cell systems, kidney organoids derived from iPS cells, and rodent models. Our Resource Development Core supports state-of-the-art imaging and is developing new imaging tools and techniques to accelerate kidney-focused research. An Administrative Core supports summer student enrichment and lay education programs. Information regarding use of our core facilities is available on our website: http://www.kidneycenter.pitt.edu

Funding

  • NIDDK