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Kidney Week

Abstract: SA-PO663

Characteristics of Registered Research in Peritoneal Dialysis, Past and Present

Session Information

  • Home Dialysis - II
    November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

  • 802 Dialysis: Home Dialysis and Peritoneal Dialysis

Authors

  • Li, Martin L., Brown University Warren Alpert Medical School, Providence, Rhode Island, United States
  • Bajaj, Ankush, Brown University Warren Alpert Medical School, Providence, Rhode Island, United States
  • Bhetuwal, Uttam, Rhode Island Hospital, Providence, Rhode Island, United States
  • Shah, Ankur, Brown University Warren Alpert Medical School, Providence, Rhode Island, United States
Background

Recent national policy changes and the continued growth of peritoneal dialysis (PD) as a therapy for end-stage kidney disease has renewed interest in this modality. The objective of this study was to describe the current landscape of PD clinical trials to assess trends and gaps in clinical research.

Methods

An advanced search was completed through ClinicalTrials.gov, yielding 248 studies. Descriptive statistics and Fisher exact tests were used for statistical analysis.

Results

Most studies were completed (197, 79.4%), did not indicate a phase (143, 57.7%), were academically sponsored (156, 62.9%), or conducted in Asia (88, 35.5%). There has been overall growth in PD clinical trials since 1995. Drug studies were more likely to be completed, industry-sponsored, or have surrogate as the primary outcome compared to device, procedure/behavioral, and other studies (17, 77.2%, 16, 72.7%, 71, 72.5%, respectively; p = 0.030; 2, 9.1%, 2, 9.1%, 5, 4.1%, respectively; p < 0.001; 13, 59.1%, 15, 68.2%, 78, 79.5%, respectively; p < 0.001).

Conclusion

Despite growth in PD research worldwide, more studies are being conducted outside the U.S., and static investment in U.S. government sponsored PD research risks not achieving the goal of increasing availability of home dialysis.