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Abstract: FR-PO908

Association Between Family Longevity and Kidney Function in Ashkenazi Jewish Older Adults

Session Information

  • Geriatric Nephrology
    November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Geriatric Nephrology

  • 1300 Geriatric Nephrology

Authors

  • Alzyood, Laith, Albert Einstein College of Medicine, Bronx, New York, United States
  • Graham, Garry Anthony, Albert Einstein College of Medicine, Bronx, New York, United States
  • Aleksic, Sandra, Albert Einstein College of Medicine, Bronx, New York, United States
  • Gao, Tina, Albert Einstein College of Medicine, Bronx, New York, United States
  • Milman, Sofiya, Albert Einstein College of Medicine, Bronx, New York, United States
  • Chen, Wei, Albert Einstein College of Medicine, Bronx, New York, United States

Group or Team Name

  • LonGenity.
Background

Familial longevity is associated with protection against age-related diseases; thus, studying familial longevity may provide insights into the mechanisms that protect against age-related decline in kidney function, which are not fully understood. LonGenity is a longitudinal cohort study of community dwelling Ashkenazi Jewish adults aged 65-94 years that aims to identify genetic determinants of familial longevity. Using this cohort, we hypothesized that offspring of parents with exceptional longevity (OPEL) had better kidney function than offspring of parents with usual survival (OPUS).

Methods

In this cross-sectional study, we used multiple linear regression to compare eGFR between OPEL (n=442, defined as having at least 1 parent living past the age of 95 years) and OPUS (n=455, defined as having neither parent who survived to 95 years). eGFR was calculated based on serum creatinine, age and sex using the CKD-EPI equation.

Results

Compared to OPUS, OPEL were younger (74 vs. 77 years), more likely to be female (59% vs. 51%), and less likely to have diabetes mellitus (7% vs. 11%), hypertension (37% vs. 50%) and cardiovascular disease (11% vs. 19%). OPEL had higher mean eGFR than OPUS (73±16 vs. 70±18 ml/min/1.73m2, p=0.001; Table). This association remained significant after adjusting for body mass index, socioeconomic status, diabetes and cardiovascular disease (p=0.03), but became non-significant after further adjusting for hypertension.

Conclusion

Using this unique cohort, we found familial propensity for longevity was associated with better kidney function independent of diabetes and cardiovascular disease, but this became nonsignificant after adjusting for hypertension. Whether hypertension mediates the relationship between familial longevity and kidney function needs further investigation.

Multiple linear regression of eGFR with familial longevity (OPEL vs. OPUS)
 β (95% confidence interval)p
Unadjusted3.85 (1.62, 6.08)0.001
Model 1: body mass index, socioeconomic status3.17 (0.90, 5.44)0.006
Model 2: 1 plus diabetes mellitus, cardiovascular disease2.51 (0.26, 4.77)0.03
Model 3: 2 plus hypertension1.76 (-0.55, 4.07)0.14

Funding

  • NIDDK Support