Abstract: SA-PO266
Dapagliflozin Ameliorates Cisplatin-Induced Nephrotoxicity by Upregulating Nuclear Factor Erythroid 2-Related Factor 2/Heme Oxygenase-1 Signaling Pathway: A Pre-Clinical Molecular Approach
Session Information
- Pharmacology: Kinetics, Genomics, Medication-Related Problems
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pharmacology (PharmacoKinetics, -Dynamics, -Genomics)
- 2000 Pharmacology (PharmacoKinetics, -Dynamics, -Genomics)
Authors
- Nair, Anuradha Asokan, Ras Al Khaimah Medical and Health Sciences University College of Medical Sciences, Ras Al Khaimah, Ra’s al Khaymah, United Arab Emirates
- Farook, Mohamed, Ras Al Khaimah Medical and Health Sciences University College of Medical Sciences, Ras Al Khaimah, Ra’s al Khaymah, United Arab Emirates
- Binu, Nirmal Nachiketh, Ras Al Khaimah Medical and Health Sciences University College of Medical Sciences, Ras Al Khaimah, Ra’s al Khaymah, United Arab Emirates
- Khan, Sofiya, Ras Al Khaimah Medical and Health Sciences University College of Medical Sciences, Ras Al Khaimah, Ra’s al Khaymah, United Arab Emirates
- Mohamed Mustafa, Mohamed Yehya, Ras Al Khaimah Medical and Health Sciences University College of Medical Sciences, Ras Al Khaimah, Ra’s al Khaymah, United Arab Emirates
- Khan, Mohammed Moin, Ras Al Khaimah Medical and Health Sciences University College of Medical Sciences, Ras Al Khaimah, Ra’s al Khaymah, United Arab Emirates
- Satyam, Shakta Mani, Ras Al Khaimah Medical and Health Sciences University College of Medical Sciences, Ras Al Khaimah, Ra’s al Khaymah, United Arab Emirates
- Bairy, Laxminarayana Kurady, Ras Al Khaimah Medical and Health Sciences University College of Medical Sciences, Ras Al Khaimah, Ra’s al Khaymah, United Arab Emirates
- Rehman, Abdul, Ras Al Khaimah Medical and Health Sciences University College of Medical Sciences, Ras Al Khaimah, Ra’s al Khaymah, United Arab Emirates
Group or Team Name
- Dr. Satyam's Lab - DAPA CKD Team.
Background
A dose-limiting side effect of cisplatin administration is nephrotoxicity which impairs a patient's quality of life. No potent nephroprotective agent is available to combat cisplatin-induced nephrotoxicity. This study aimed to explore the nephroprotective potential of dapagliflozin and silymarin alone and in combination against cisplatin-induced nephrotoxicity in Wistar rats.
Methods
30 adult Wistar rats were randomly divided into five groups (n=6/group): Group I- Normal control, Group II- Negative control, Group- III- Silymarin, Group IV- Dapagliflozin and Group V- Dapagliflozin + Silymarin. Nephrotoxicity was induced in Group II to Group V by administering cisplatin weekly for seven weeks. Biomarkers for kidney injury, inflammation, and oxidative stress were estimated following a histopathological examination of the kidney.
Results
Chronic kidney disease was significantly (p<0.05) demonstrated in cisplatin-intoxicated (negative) control
compared to normal control rats. Dapagliflozin alone and in combination with silymarin significantly (p<0.05) reduced serum urea, creatinine, inflammatory cytokines, and oxidative stress markers compared to negative control.
Conclusion
The present study revealed that dapagliflozin alone and in combination with silymarin ameliorates cisplatin-induced nephrotoxicity in Wistar rats via stimulating Nrf2/HO-1 signaling pathway.