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Abstract: SA-PO667

Retinopathy Is Associated with Impaired Cognition in Patients Undergoing Peritoneal Dialysis

Session Information

  • Home Dialysis - II
    November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

  • 802 Dialysis: Home Dialysis and Peritoneal Dialysis

Authors

  • Liao, Jinlan, Peking University Shenzhen Hospital, Shenzhen, GuangDong, China
  • Wei, Qijie, Vistel AI Lab, Beijing, China
  • He, Ying Ying, Peking University Shenzhen Hospital, Shenzhen, GuangDong, China
  • Liao, Yumei, Peking University Shenzhen Hospital, Shenzhen, GuangDong, China
  • Xiong, Zibo, Peking University Shenzhen Hospital, Shenzhen, GuangDong, China
  • Wang, Qing, Peking University Shenzhen Hospital, Shenzhen, GuangDong, China
  • Ding, Dayong, Vistel AI Lab, Beijing, China
  • Huang, Xiaoyan, Peking University Shenzhen Hospital, Shenzhen, GuangDong, China
  • Xiong, Zuying, Peking University Shenzhen Hospital, Shenzhen, GuangDong, China
  • Wu, Yonggui, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Background

This study was aimed at examining the relationship between retinopathy and cognitive impairment in patients undergoing peritoneal dialysis (PD).

Methods

Forty-eight men and 59 women (age range: 21 to 78 years) undergoing PD were included in this cross-sectional study. Retinal microvascular characteristics, such as geometric changes in retinal vascular including tortuosity, fractal dimension (FD), and calibers, were assessed. Retinopathy (such as retinal hemorrhage or microaneurysms) was evaluated using digitized photographs. The Modified Mini-Mental State Examination (3MS) was performed to assess global cognitive function.

Results

The prevalence rates of retinal hemorrhage, microaneurysms, and retinopathy were 25%, 30%, and 43%, respectively. The mean arteriolar and venular calibers were 63.2 and 78.5 mm, respectively, and the corresponding mean tortuosity was 37.7 ± 3.6 and 37.2 ± 3.0 mm-1. The mean FD was 1.49. After adjusting for age, sex, education, mean arterial pressure, and Charlson index, retinopathy was found to be negatively associated with 3MS scores (regression coefficient, -3.71, 95% confidence interval: -7.09 to -0.33, P = 0.03).

Conclusion

Retinopathy, a condition common in patients undergoing PD, was associated with global cognitive impairment.

Table 1 Evaluation of retinal microvascular characteristics

Figure 1 Subgroup analysis of associations between retinopathy and 3MS scores.

Funding

  • Government Support – Non-U.S.