Abstract: FR-PO416
Self- and Observer-Rated Computer-Based Cognitive Function and Abilities Tests Are Valid for Dialysis Patients
Session Information
- Hemodialysis: Quality of Life, Symptoms, Palliative Care
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Cromm, Krister, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Hessen, Germany
- Tunçel, Özlem Kuman, Ege Universitesi, Izmir, İzmir, Turkey
- Humpert, Mirja, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Hessen, Germany
- Pham, Le Hong Ngoc, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Hessen, Germany
- De los Ríos, Tatiana, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Hessen, Germany
- Çelik, Yusuf, Marmara Universitesi, Istanbul, Istanbul, Turkey
- Agirbas, Ismail, Ankara Universitesi, Ankara, Ankara, Turkey
- Bedel, Tugce, Ege Universitesi, Izmir, İzmir, Turkey
- Kaletas, Sibel, Ege Universitesi, Izmir, İzmir, Turkey
- Asci, Gulay, Ege Universitesi, Izmir, İzmir, Turkey
- Houts, Carrie R., Vector Psychometric Group, LLC, Chapel Hill, North Carolina, United States
- Wirth, RJ, Vector Psychometric Group, LLC, Chapel Hill, North Carolina, United States
- Ok, Ercan, Ege Universitesi, Izmir, İzmir, Turkey
- Elbi, Hayriye, Ege Universitesi, Izmir, İzmir, Turkey
Group or Team Name
- DOPRO.
Background
Cognitive Function and Abilities (CFA) are important factors in health-related quality of life (HRQOL) of dialysis patients and a prerequisite for performing hemodialysis (HD) at home. Congruence of self- and observer-reported CFA is debated for assessment in clinical trials. The purpose of the study was to support the use of a CFA measure in Turkish HD patients.
Methods
We translated the 31-item PROMIS (Patient-Reported Outcomes Measurement Information System) CFA (PROMIS-CFA) subset according to FACIT methodology. PROMIS-CFA was filled in electronically by participants, Addenbrooke’s Cognitive Examination-Revised (ACE-R) was assessed by psychologists at the same time during dialysis sessions. HRQOL was assessed with KDQOL-SF. Psychologist called participants on the next day for 16-item Telephone Cognitive Screen (T-Cog-S). Among 1164 patients treated in the 7 dialysis clinics, eligible patients were screened, and 151 in-center conventional HD and 26 home HD patients were randomly selected.
Results
The final sample was composed of 63 females and 114 males with an average age of 55.5±13.4. The average time since kidney disease diagnosis was 10.4±8.2 years and the average time on dialysis was 74.4±66 months. Thirty-four patients had mild cognitive impairment based on categorized ACE-R scores. The internal consistency (Cronbach’s α) for the PROMIS-CFA was .96 and the observed test-retest intraclass correlation coefficient over approximately 7 days was r=.70. There were significant but low correlations (r=.2-.28) between ACE-R and PROMIS-CFA scores, but higher correlations with HRQOL (r=.15-.44). T-Cog-S significantly correlated with ACE-R (r=.55), but not PROMIS-CFA.
Conclusion
The Turkish translation of PROMIS-CFA is reliable and may support valid inferences regarding cognitive functioning and abilities in this population. Self-rated CFA is more closely related to HRQOL than observer-rated CFA. Future outcome studies should therefore include both assessments in larger samples. Telephone interviewing with T-Cog-S was not an alternative to clinical evaluation in detecting cognitive impairment due to high ceiling effects.
Funding
- Commercial Support – Fresenius Medical Care Deutschland GmbH