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Abstract: FR-PO416

Self- and Observer-Rated Computer-Based Cognitive Function and Abilities Tests Are Valid for Dialysis Patients

Session Information

Category: Dialysis

  • 801 Dialysis: Hemodialysis and Frequent Dialysis


  • Cromm, Krister, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Hessen, Germany
  • Tunçel, Özlem Kuman, Ege Universitesi, Izmir, İzmir, Turkey
  • Humpert, Mirja, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Hessen, Germany
  • Pham, Le Hong Ngoc, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Hessen, Germany
  • De los Ríos, Tatiana, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Hessen, Germany
  • Çelik, Yusuf, Marmara Universitesi, Istanbul, Istanbul, Turkey
  • Agirbas, Ismail, Ankara Universitesi, Ankara, Ankara, Turkey
  • Bedel, Tugce, Ege Universitesi, Izmir, İzmir, Turkey
  • Kaletas, Sibel, Ege Universitesi, Izmir, İzmir, Turkey
  • Asci, Gulay, Ege Universitesi, Izmir, İzmir, Turkey
  • Houts, Carrie R., Vector Psychometric Group, LLC, Chapel Hill, North Carolina, United States
  • Wirth, RJ, Vector Psychometric Group, LLC, Chapel Hill, North Carolina, United States
  • Ok, Ercan, Ege Universitesi, Izmir, İzmir, Turkey
  • Elbi, Hayriye, Ege Universitesi, Izmir, İzmir, Turkey

Group or Team Name

  • DOPRO.

Cognitive Function and Abilities (CFA) are important factors in health-related quality of life (HRQOL) of dialysis patients and a prerequisite for performing hemodialysis (HD) at home. Congruence of self- and observer-reported CFA is debated for assessment in clinical trials. The purpose of the study was to support the use of a CFA measure in Turkish HD patients.


We translated the 31-item PROMIS (Patient-Reported Outcomes Measurement Information System) CFA (PROMIS-CFA) subset according to FACIT methodology. PROMIS-CFA was filled in electronically by participants, Addenbrooke’s Cognitive Examination-Revised (ACE-R) was assessed by psychologists at the same time during dialysis sessions. HRQOL was assessed with KDQOL-SF. Psychologist called participants on the next day for 16-item Telephone Cognitive Screen (T-Cog-S). Among 1164 patients treated in the 7 dialysis clinics, eligible patients were screened, and 151 in-center conventional HD and 26 home HD patients were randomly selected.


The final sample was composed of 63 females and 114 males with an average age of 55.5±13.4. The average time since kidney disease diagnosis was 10.4±8.2 years and the average time on dialysis was 74.4±66 months. Thirty-four patients had mild cognitive impairment based on categorized ACE-R scores. The internal consistency (Cronbach’s α) for the PROMIS-CFA was .96 and the observed test-retest intraclass correlation coefficient over approximately 7 days was r=.70. There were significant but low correlations (r=.2-.28) between ACE-R and PROMIS-CFA scores, but higher correlations with HRQOL (r=.15-.44). T-Cog-S significantly correlated with ACE-R (r=.55), but not PROMIS-CFA.


The Turkish translation of PROMIS-CFA is reliable and may support valid inferences regarding cognitive functioning and abilities in this population. Self-rated CFA is more closely related to HRQOL than observer-rated CFA. Future outcome studies should therefore include both assessments in larger samples. Telephone interviewing with T-Cog-S was not an alternative to clinical evaluation in detecting cognitive impairment due to high ceiling effects.


  • Commercial Support – Fresenius Medical Care Deutschland GmbH