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Kidney Week

Abstract: SA-PO459

Association of Peripheral Neutrophil Count with Risk of Cardiovascular Mortality Among Adults with Diabetic Kidney Disease: Evidence from NHANES 2005-2010

Session Information

Category: Diabetic Kidney Disease

  • 702 Diabetic Kidney Disease: Clinical

Authors

  • Xie, Ruiyan, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
  • Sher, Ka Ho Jason, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
  • Zhang, Danting, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
  • Yap, Yat Hin Desmond, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China

Group or Team Name

  • Dr. Yap, Yat Hin Desmond Team.
Background

Accumulating data shows that chronic inflammation has crucial pathogenic contributions in CKD patients with diabetes, but the contribution of neutrophils count in diabetic kidney disease (DKD) remains elusive.

Methods

We performed a cross-sectional study of 44,494 participants in the National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2020. The prevalence of CKD and diabetes were calculated. The association of peripheral neutrophils count levels with kidney functions in DKD and cardiovascular disease (CVD) mortality were further explored using logistic regression and Cox proportional hazards models.

Results

Among the 2,643 patients with DKD from NHANES, the weighted mean of peripheral neutrophil count level was 4.97. When compared with patients with DKD in the lowest neutrophil count quintile, The highest quintile had the positively association with uACR and negatively relationship with estimated eGFR. During 2,215 person-years of eligible follow-up, 766 deaths (n = 237 deaths from CVD) occurred. In comparison to those in the those in the lowest neutrophil count quintile group, the highest quintile group had the HRs of 1.77 for all-cause mortality and 2.24 for CVD mortality in the fully adjusted model. A linear count-response relationship of peripheral neutrophil count with CVD mortality were also demonstrated (P=0.002).

Conclusion

Higher peripheral neutrophil count was significantly associated with an increased risk of cardiovascular mortality and poor kidney function among patients with DKD.

Funding

  • Private Foundation Support