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Abstract: SA-PO451

Epidemiology of Diabetic CKD in Rural and Peri-Urban Bangladesh

Session Information

Category: Diabetic Kidney Disease

  • 702 Diabetic Kidney Disease: Clinical

Authors

  • Sarker, Mohammad Habibur Rahman, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Dhaka District, Bangladesh
  • Rahman, Md Moshiur, Hiroshima Daigaku Daigakuin Ikei Kagaku Kenkyuka, Hiroshima, Hiroshima, Japan
  • Sujon, Hasnat, Medizinische Hochschule Hannover, Hannover, Niedersachsen, Germany
  • Banu, Shakila, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Dhaka District, Bangladesh
  • Chisti, Mohammod Jobayer, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Dhaka District, Bangladesh
  • Faruque, Asg, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Dhaka District, Bangladesh
Background

Diabetes is often compounded with chronic kidney disease, and both diseases are becoming more prevalent. However, epidemiological data on Diabetic Chronic Kidney Disease (DCKD) is largely lacking in developing countries. We aimed to generate data in evaluating the prevalence of DCKD and associated risk factors in a selected rural community in Bangladesh.

Methods

We recruited study patients from the Mirzapur Demographic Surveillance System by stratified random sampling. We performed fasting blood sugar to screen patients for diabetes, and measured serum creatinine and urine albumin to creatinine ratio followed by a repeat measurement after 3 months to diagnose CKD. The GFR was estimated using the CKD Epidemiology Collaboration equation, and CKD was diagnosed using the Kidney Disease Outcomes Quality Initiative guidelines. Additionally, age, gender, marital status, occupation, educational background, income/month, smoking status, and sleeping hours were acquired during interviews. Physical examinations were performed to determine blood pressure, pulse rate, height, weight, waist circumference, and hip circumference. Moreover, blood samples were collected to measure serum albumin, hemoglobin, total cholesterol and triglyceride Chi-square test was performed for estimation of odds ratios (OR) and their 95% confidence intervals (CI) to determine the strength of association. Variables with P-values <0.05 were simultaneously included into the multivariate logistic model and adjusted odds ratio (aOR) and 95% CI were estimated.

Results

The prevalence of DCKD was 7.0% (61 cases of 872 screened participants). In multivariable analysis, associated factors for prevalent DCKD included hypertension (aOR 2.18, 95% CI 1.21-3.94), low serum albumin (aOR 2.24, 95% CI 1.00-5.00), and hypertriglyceridemia (aOR 2.14, 95% CI 1.21-3.79). However, there was no significant association between DCKD and those aged 46 years and more, sleeping duration less than 7 hours per day, present tobacco smokers, abdominal obesity, and hypercholesterolemia.

Conclusion

This epidemiological data on DCKD in rural and peri-urban Bangladesh revealed a 7% prevalence of DCKD. An early detection system to diagnose DCKD and the intervention should be scaled up to curb the risk factors, such as hypertension, low serum albumin, and hypertriglyceridemia.

Funding

  • Private Foundation Support