Abstract: SA-PO1088
Post-Transplant Lymphoproliferative Disorders in Kidney Transplant Recipients: A Retrospective Single-Center Cohort Analysis
Session Information
- Transplantation: Clinical - II
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Jan, Muhammad Yahya, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Kelly, Bethany, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Raza, Ahsan, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Adebiyi, Oluwafisayo O., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Yaqub, Muhammad S., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Sharfuddin, Asif A., Indiana University School of Medicine, Indianapolis, Indiana, United States
Background
To characterize the posttransplant lymphoproliferative disorders(PTLD) including the Epstein-Barr virus (EBV) status, histological subgroups, site of occurrence and the clinical outcomes of kidney transplant recipients at our institution.
Methods
A retrospective cohort study of all kidney transplant recipients who developed PTLD and were followed up at our transplant centers from 1999 through 2021.
Results
44 patients developed PTLD, with majority 86.4% being kidney alone transplants, while 13.6% were Kidney-Pancreas recipients. Heme-Oncology were primarily responsible for the treatments which was tailored to their individual type and stage and site of PTLD. Immunosuppression was lowered on an individualized basis.
Conclusion
We describe a large series of PTLD cases, with their outcomes with reasonable outcomes. The time-line to PTLD was not limited to early post-transplant course as seen in other series, and EBV-ve PTLD was more common. Careful adjustment of immunosuppression, early detection, and aggressive treatment can lead to acceptable outcomes.