Abstract: FR-PO126
Association of Dynamic Hemoglobin Change and Renal Recovery in Patients with Severe AKI Requiring Continuous Renal Replacement Therapy
Session Information
- AKI: Outcomes, RRT
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 102 AKI: Clinical, Outcomes, and Trials
Authors
- Nam, Areumsongi, Dongguk University Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
- Jung, Jiyun, Dongguk University Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
- Kim, Jungsoon, Dongguk University Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
- Im, Dha Woon, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Kim, Yong Chul, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Lee, Jangwook, Dongguk University Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
- Shin, Sung Joon, Dongguk University Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
- Park, Jae Yoon, Dongguk University Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
Group or Team Name
- Dept of Internal Medicine, Dongguk University Ilsan Hospital.
Background
Anemia in patients with severe acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is associated with increased mortality and morbidity. However, the relevance of dynamic hemoglobin level variability (HbV) to renal recovery after AKI is still largely unknown. This study investigated the correlations between HbV and renal recovery at the time of discharge in patients with severe AKI who requiring CRRT.
Methods
We collected 1,897 AKI patients who underwent CRRT from two university hospitals between 2006 and 2021. The HbV was defined as the standard deviation (SD) and coefficient of variation (CV) during CRRT. To investigate the effects of HbV on RRT-dependence at discharge, we estimated the sub-distribution hazard ratio (HR) considering the mortality, adjusted by sex, age, charlson-comorbidity index, hypertension, SOFA, APACHE, and serum chemistry data.
Results
Of 1,897 AKI patients, 38 % were male, and the mean (standardized deviation) age was 66.1 (16.1) years. The proportion of outcome at discharge was 8% for RRT dependence, 29% for RRT independence, and 63% for mortality. The Cox regression analysis showed that HbV was positively correlated with RRT-dependence (SD, HR 0.77, 95% confidence interval [CI], 0.66 to 0.89; CV, HR 0.97; 95% CI 0.96 to 0.99).
Conclusion
This study showed that HbV during dialysis was associated with short-term renal recovery after severe AKI requiring CRRT.